The effects of cantharidin analogues on xanthine oxidase

Wei Tsauer, Jaung Geng Lin, Pen Yuan Lin, Feng Lin Hsu, Hsuch Ching Chiang

研究成果: 雜誌貢獻文章同行評審

42 引文 斯高帕斯(Scopus)

摘要

Norcantharidin, the demethylated product of cantharidin has been used for the treatment of hepatoma, carcinomas of esophagus and gastric cardia, leukopenia and hepatitis. Since the enzyme xanthine oxidase is involved in the diseases mentioned above, and the reactive oxygen species produced by the enzyme induces DNA damage and oxidative damage of tissues, fourteen cantharidin analogues and cantharidimide derivatives were tested for their effects on xanthine oxidase. The results showed that these compounds displayed very weak inhibitory effects on xanthine oxidase. Contrary to expectation disodium cantharidate, Norcantharidin, dehydronorcantharidin, disodium dehydronorcantharidate, N-(2-pyridyl) cantharidimide, N-(3-pyridyl) cantharidimide and N-(4-pyridyl) cantharidimide showed a slight stimulating effect on xanthine oxidase at several concentrations.

原文英語
頁(從 - 到)2095-2098
頁數4
期刊Anticancer Research
17
發行號3 C
出版狀態已發佈 - 1997

ASJC Scopus subject areas

  • 癌症研究
  • 腫瘤科

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