摘要
| 原文 | 英語 |
|---|---|
| 頁（從 - 到） | 286-290 |
| 頁數 | 5 |
| 期刊 | Brain Research |
| 卷 | 865 |
| 發行號 | 2 |
| DOIs | |
| 出版狀態 | 已發佈 - 五月 26 2000 |
| 對外發佈 | Yes |
指紋
ASJC Scopus subject areas
- Neuroscience(all)
引用此文
The effect of steroid sulfatase inhibition on learning and spatial memory. / Johnson, David A.; Wu, Tzu Hua; Li, Pui Kai; Maher, Timothy J.
於: Brain Research, 卷 865, 編號 2, 26.05.2000, p. 286-290.研究成果: 雜誌貢獻 › 文章
}
TY - JOUR
T1 - The effect of steroid sulfatase inhibition on learning and spatial memory
AU - Johnson, David A.
AU - Wu, Tzu Hua
AU - Li, Pui Kai
AU - Maher, Timothy J.
PY - 2000/5/26
Y1 - 2000/5/26
N2 - Steroid sulfatase inhibitors can enhance the concentration of the neurosteroid DHEAS in rat brain. Previous studies have demonstrated that the steroid sulfatase inhibitor (p-O-sulfamoyl)-N-tetradecanoyl tyramine (DU-14) could reverse scopolamine induced amnesia in rats in a passive avoidance memory paradigm. The intent of this study was to determine whether chronic pretreatment with DU-14 could reverse scopolamine amnesia and/or enhance spacial memory in the place, probe and cued versions of the Morris water maze (MWM). Rats were divided into four groups and administered IP for 15 days either DU-14 (30.0 mg/Kg) or corn oil (1.0 ml/Kg) vehicle. On training days animals were administered either scopolamine (1.0 mg/Kg) or saline (1.0 ml/Kg). The groups administered DU-14 displayed a significant enhancement in learning and spacial memory in the place version of the MWM, when compared to respective vehicle-scopolamine and vehicle-saline groups. In the probe version, the DU-14-saline group remained in the target quadrant of the maze significantly longer than any of the other groups indicating enhanced retention. In the cued version of the MWM, treatment with DU-14 did not significantly change escape latency suggesting that the steroid sulfatase inhibitor did not alter motivation or locomotion. These results suggest that the chronic administration of steroid sulfatase inhibitors enhance learning and spatial memory in rats. Themes: Neural basis of behavior. Topics: Learning and memory: pharmacology. Copyright (C) 2000.
AB - Steroid sulfatase inhibitors can enhance the concentration of the neurosteroid DHEAS in rat brain. Previous studies have demonstrated that the steroid sulfatase inhibitor (p-O-sulfamoyl)-N-tetradecanoyl tyramine (DU-14) could reverse scopolamine induced amnesia in rats in a passive avoidance memory paradigm. The intent of this study was to determine whether chronic pretreatment with DU-14 could reverse scopolamine amnesia and/or enhance spacial memory in the place, probe and cued versions of the Morris water maze (MWM). Rats were divided into four groups and administered IP for 15 days either DU-14 (30.0 mg/Kg) or corn oil (1.0 ml/Kg) vehicle. On training days animals were administered either scopolamine (1.0 mg/Kg) or saline (1.0 ml/Kg). The groups administered DU-14 displayed a significant enhancement in learning and spacial memory in the place version of the MWM, when compared to respective vehicle-scopolamine and vehicle-saline groups. In the probe version, the DU-14-saline group remained in the target quadrant of the maze significantly longer than any of the other groups indicating enhanced retention. In the cued version of the MWM, treatment with DU-14 did not significantly change escape latency suggesting that the steroid sulfatase inhibitor did not alter motivation or locomotion. These results suggest that the chronic administration of steroid sulfatase inhibitors enhance learning and spatial memory in rats. Themes: Neural basis of behavior. Topics: Learning and memory: pharmacology. Copyright (C) 2000.
KW - DHEAS
KW - Learning and memory
KW - Learning and memory: pharmacology
KW - Morris water maze
KW - Neural basis of behavior
KW - Neurosteroid
KW - Steroid sulfatase inhibitor
UR - http://www.scopus.com/inward/record.url?scp=0034716954&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0034716954&partnerID=8YFLogxK
U2 - 10.1016/S0006-8993(00)02372-6
DO - 10.1016/S0006-8993(00)02372-6
M3 - Article
C2 - 10821934
AN - SCOPUS:0034716954
VL - 865
SP - 286
EP - 290
JO - Brain Research
JF - Brain Research
SN - 0006-8993
IS - 2
ER -