The effect of moderate endurance training on cardioprotective molecule adaptations

Zong Yan Cai, Cheng Chen Hsu, Mei Chich Hsu, Mao Shung Huang, Chao Pin Yang, Yung Yu Tsai, Borcherng Su

研究成果: 雜誌貢獻文章同行評審

1 引文 斯高帕斯(Scopus)

摘要

Purpose: This study aimed to investigate the effect of moderate endurance training on cardio-protective molecule adaptations, including marker of stem cell activation in the myocardium. Materials and Methods: Twenty-four Spra-gue-Dawley rats were randomly divided into a 4-wk exercise training (4WT) group, a 4-wk sedentary control (4WC) group, an 8-wk exercise training (8WT) group, and an 8-wk sedentary control (8WC) group (n=6 respectively). The training protocol consisted of treadmill running at 20 m/ min for 30 min on a 0% grade, for 3 days/wk. Immunohistochemistry staining coupled with image analysis, as expressed by mean optical density, was used for protein quantification.Results: The results indicated that the heat shock protein (HSP70) and stem cell marker, as evaluated by c-kit, were higher in 4WT than those in the 4WC and 8WT group (p <0.05), and the HSP70 content in the 8WT was higher than that of the 8WC group. In addition, 4WT and 8WT groups exhibited a significantly higher hepatocyte growth factor (HGF) and c-met content compared to their respective control counterparts (p

原文英語
頁(從 - 到)1912-1920
頁數9
期刊HealthMED
5
發行號6 SUPPL. 1
出版狀態已發佈 - 2011

ASJC Scopus subject areas

  • 醫藥 (全部)

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