The effect of hyperbaric oxygen and air on cartilage tissue engineering

Juin-Hong Cherng, Shun-Cheng Chang, Shyi-Gen Chen, Ming-Lun Hsu, Po-Da Hong, Shou-Chen Teng, Yi-Hsin Chan, Chih-Hsin Wang, Tim-Mo Chen, Niann-Tzyy Dai

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16 引文 斯高帕斯(Scopus)


There is an urgent need to develop tissue-engineered cartilage for patients experiencing joint malfunction due to insufficient self-repairing capacity of articular cartilage. The aim of this research was to explore the effect of hyperbaric oxygen and air on tissue-engineered cartilage formation from human adipose-derived stem cells seeding on the gelatin/polycaprolactone biocomposites. The results of histological analyses indicate that under hyperbaric oxygen and air stimulation, the cell number of chondrocytes in cartilage matrix was not significantly increased, but the 1,9-dimethylmethylene blue assay showed that the glycosaminoglycans syntheses markedly increased compared to the control group. In quantification real-time polymerase chain reaction results, the chondrogenic-specific gene expression of SOX9, aggrecan, and COL2A1 were compared respectively. Within the limitation of this study, it was concluded that 2.5 atmosphere absolute oxygen and air may provide a stress environment to help cartilage tissue engineering development. Copyright © 2012 by Lippincott Williams & Wilkins.
頁(從 - 到)650-655
期刊Annals of Plastic Surgery
出版狀態已發佈 - 2012


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