The effect of endogenous nitric oxide on neurogenic plasma exudation in guinea-pig airways

Kuo Han-Pin, Liu Shufang, Peter J. Barnes

研究成果: 雜誌貢獻文章同行評審

109 引文 斯高帕斯(Scopus)

摘要

We studied the effect of endogenous nitric oxide (NO) on vagally induced plasma exudation into guinea-pig trachea and main bronchi using 125I-albumin as a plasma marker. NG-Nitro-L-arginine methyl ester (L-NAME, 1-10 mg/kg) dose dependently inhibited neurogenic plasma exudation. Intravenous phenylephrine which simulated the vasopressor effect as L-NAME (10 mg/kg) was without effect. The effect of L-NAME (5 mg/kg) was reversed by L-arginine (50 mg/kg). These results suggest that endogenous NO may contribute to neurogenic inflammation in the airways.

原文英語
頁(從 - 到)385-388
頁數4
期刊European Journal of Pharmacology
221
發行號2-3
DOIs
出版狀態已發佈 - 十月 20 1992
對外發佈

ASJC Scopus subject areas

  • 藥理

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