The effect of combined steroid and calcium channel blocker injection on human hypertrophic scars in animal model: A new strategy for the treatment of hypertrophic scars

Jui Yung Yang, Chun Yuan Huang

研究成果: 雜誌貢獻文章同行評審

34 引文 斯高帕斯(Scopus)

摘要

Background Hypertrophic scars (HScs) are inelastic scars that can cause functional loss and disfigurement. Decorin regulates collagen fibrillogenesis, and its expression is lower in HScs than in normal skin and during wound healing. Objective To evaluate the efficacy of combined verapamil and triamcinolone in treating HScs. Methods Excised human HSc fragments from surgically treated burned patients were divided into three groups: A (normal saline), B (verapamil), and C (verapamil and triamcinolone). The specimens were bilaterally implanted in the back of nude mice, treated using intralesional injections, and observed for 4 weeks. We compared the fibroblast viability and proliferation, decorin staining, and scar weights to evaluate treatment efficacy. Results Viability and proliferation of HSc fibroblasts from groups B and C were significantly lower at all time intervals after transplantation (p

原文英語
頁(從 - 到)1942-1949
頁數8
期刊Dermatologic Surgery
36
發行號12
DOIs
出版狀態已發佈 - 12月 2010

ASJC Scopus subject areas

  • 皮膚科
  • 手術

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