The effect of cerebrospinal fluid dilution of isobaric 0.5% bupivacaine used for spinal anaesthesia

Y. G. Cherng, H. H. Huang, T. G. Chen, C. L. Huang

研究成果: 雜誌貢獻文章

2 引文 (Scopus)

摘要

A prospective study was conducted to see the effect on spinal anaesthesia of the dilution of isobaric 0.5% bupivacaine with cerebrospinal fluid. Sixty patients were randomly allocated to three groups. In group 1, patients received 3 ml isobaric 0.5% bupivacaine intrathecally without aspirating cerebrospinal fluid. In groups 2 and 3, cerebrospinal fluid 1 ml and 2 ml was aspirated respectively and mixed with 3 ml isobaric 0.5% bupivacaine. A total volume of 4 ml in group 2 and 5 ml in group 3 was administered. Thus, the volume of cerebrospinal fluid remained unchanged. Pinprick analgesia and motor block was evaluated from induction until recovery. No differences in onset time, duration and 'two segments regression' were noticed. The only statistical difference was the time to reach complete motor block, which was shorter in group 1 as compared to groups 2 and 3 (6.9 SD 1.4 min versus 11.3 SD 3.0 and 13.5 SD 3.9 min respectively). The mean value of maximum decrease in systolic blood pressure was small, being less than 15% of the pre-operative value for each group. In conclusion, the effect of diluting isobaric 0.5% bupivacaine with cerebrospinal fluid, 1 ml and 2 ml, is minimal and it is an unnecessary procedure with limited clinical effect.

原文英語
頁(從 - 到)906-909
頁數4
期刊Anaesthesia
50
發行號10
DOIs
出版狀態已發佈 - 1995
對外發佈Yes

指紋

Spinal Anesthesia
Bupivacaine
Cerebrospinal Fluid
Blood Pressure
Unnecessary Procedures
Analgesia
Prospective Studies

ASJC Scopus subject areas

  • Anesthesiology and Pain Medicine

引用此文

The effect of cerebrospinal fluid dilution of isobaric 0.5% bupivacaine used for spinal anaesthesia. / Cherng, Y. G.; Huang, H. H.; Chen, T. G.; Huang, C. L.

於: Anaesthesia, 卷 50, 編號 10, 1995, p. 906-909.

研究成果: 雜誌貢獻文章

Cherng, Y. G. ; Huang, H. H. ; Chen, T. G. ; Huang, C. L. / The effect of cerebrospinal fluid dilution of isobaric 0.5% bupivacaine used for spinal anaesthesia. 於: Anaesthesia. 1995 ; 卷 50, 編號 10. 頁 906-909.
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abstract = "A prospective study was conducted to see the effect on spinal anaesthesia of the dilution of isobaric 0.5{\%} bupivacaine with cerebrospinal fluid. Sixty patients were randomly allocated to three groups. In group 1, patients received 3 ml isobaric 0.5{\%} bupivacaine intrathecally without aspirating cerebrospinal fluid. In groups 2 and 3, cerebrospinal fluid 1 ml and 2 ml was aspirated respectively and mixed with 3 ml isobaric 0.5{\%} bupivacaine. A total volume of 4 ml in group 2 and 5 ml in group 3 was administered. Thus, the volume of cerebrospinal fluid remained unchanged. Pinprick analgesia and motor block was evaluated from induction until recovery. No differences in onset time, duration and 'two segments regression' were noticed. The only statistical difference was the time to reach complete motor block, which was shorter in group 1 as compared to groups 2 and 3 (6.9 SD 1.4 min versus 11.3 SD 3.0 and 13.5 SD 3.9 min respectively). The mean value of maximum decrease in systolic blood pressure was small, being less than 15{\%} of the pre-operative value for each group. In conclusion, the effect of diluting isobaric 0.5{\%} bupivacaine with cerebrospinal fluid, 1 ml and 2 ml, is minimal and it is an unnecessary procedure with limited clinical effect.",
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