The effect of aging on the pharmacokinetics of nalbuphine in rabbits

Shung‐Tai ‐T Ho, Jhi‐Joung ‐J Wang, Oliver Yoa‐Pu Hu, Teh‐Min ‐M Hu

研究成果: 雜誌貢獻文章同行評審

5 引文 斯高帕斯(Scopus)

摘要

For the purpose of selecting an animal model for the study of the aging effect on the pharmacokinetics of nalbuphine, the pharmacokinetic properties in young and in aged rabbits were reported. Thirty‐one healthy New Zealand white rabbits ranging in ages (mean) from three months to 43 months (six three months old, group I; nine eight months old, group II; nine 18 months old, group III; and seven 43 months old, group IV) were included in the study. After intravenous bolus injection of nalbuphine (10 mg kg−1) to each rabbit, plasma samples were collected and analysed for nalbuphine by a high‐performance liquid chromatography method. The plasma concentration—time data regarding nalbuphine were successfully fitted to a linear two‐compartment open model. The elimination half‐life of nalbuphine in rabbits increased significantly with age. Consequently, clearance decreased significantly with age. The parameter AUC0‐∞, which is derived from dose/clearance, increased significantly with age. The effect of aging on the pharmacokinetics of nalbuphine in rabbits is quite similar to that in humans. From the present study, it is concluded that rabbits may be suitable for the study of aging effects on the pharmacokinetics of nalbuphine.
原文英語
頁(從 - 到)695-703
頁數9
期刊Biopharmaceutics & Drug Disposition
16
發行號8
DOIs
出版狀態已發佈 - 一月 1 1995
對外發佈

ASJC Scopus subject areas

  • 藥理
  • 藥學科學
  • 藥學(醫學)

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