The distinct roles of two GPCRs, MrgprC11 and PAR2, in itch and hyperalgesia

Qin Liu, Hao Jui Weng, Kush N. Patel, Zongxiang Tang, Haihua Bai, Martin Steinhoff, Xinzhong Dong

研究成果: 雜誌貢獻文章同行評審

151 引文 斯高帕斯(Scopus)

摘要

Itch has been defined as an unpleasant skin sensation that triggers the urge to scratch. Primary sensory dorsal root ganglia neurons detect itch stimuli through peripheral axons in the skin, playing an important role in generating itch. Itch is broadly categorized as histaminergic (sensitive to antihistamines) or nonhistaminergic. The peptide Ser-Leu-Ile-Gly-Arg-Leu (SLIGRL) is an itch-inducing agent widely used to study histamine-independent itch. Here, we show that Mrgprs (Mas-related G protein - coupled receptors), particularly MrgprC11, rather than PAR2 (protease-activated receptor 2) as previously thought, mediate this type of itch. A shorter peptide, SLIGR, which specifically activates PAR2 but not MrgprC11, induced thermal pain hypersensitivity in mice but not a scratch response. Therefore, although both Mrgpr and PAR2 are SLIGRL-responsive G protein - coupled receptors present in dorsal root ganglia, each plays a specific role in mediating itch and pain.
原文英語
文章編號ra45
期刊Science Signaling
4
發行號181
DOIs
出版狀態已發佈 - 七月 12 2011

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Cell Biology

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