The CRY box: A second APCcdh1-dependent degron in mammalian cdc20

Alexandra Reis, Mark Levasseur, Heng Yu Chang, David J. Elliott, Keith T. Jones

研究成果: 雜誌貢獻文章同行評審

60 引文 斯高帕斯(Scopus)

摘要

Cdc20 and cdh1 are coactivators of the anaphase-promoting complex (APC). APCcdc20 is necessary for the metaphase-anaphase transition and, at the end of mitosis, vertebrate cdc20 itself becomes a target for degradation through KEN-box-dependent APCcdh1 activity. By studying the degradation of fluorescent protein chimaeras in mammalian oocytes and early embryos, we found that cdc20 was degraded through two independent degradation signals (degrons), the KEN box and a newly described CRY box. In both oocytes and G1-stage embryos, the rate of degradation through the CRY box was greater than through the KEN box, although both were mediated by APCcdh1. Thus, mammalian oocytes and embryos have the capacity to recognize two degrons in cdc20.

原文英語
頁(從 - 到)1040-1045
頁數6
期刊EMBO Reports
7
發行號10
DOIs
出版狀態已發佈 - 10月 2006
對外發佈

ASJC Scopus subject areas

  • 遺傳學
  • 細胞生物學

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