The compound, diallyl disulfide, enriched in garlic, prevents the progressiodoxorubicin-induced nephropathy

San Chi Lin, Amarzaya Chagnaadorj, Uyanga Bayarsengee, Ting Kai Leung, Chao Wen Cheng

研究成果: 雜誌貢獻文章

1 引文 斯高帕斯(Scopus)

摘要

The main medicinal property of garlic is mostly attributed to its organosulfur compounds, of which the oil-soluble diallyl disulfide (DADS) is the principal component of distilled garlic oil. Nuclear factor erythroid 2-related factor 2 (Nrf2) is an important cellular regulator in response to oxidative stress. This study assessed the possible protective effect of DADS on doxorubicin (Dox)-induced nephrotoxicity and its potential regulation of the Nrf2 pathway. Treatment with DADS (200 μM) induced heme oxygenase (HO)-1 and NADPH quinone oxidoreductase 1 (NQO-1) expression in a human proximal tubular cell line. The induction of HO-1 expression was suppressed in Nrf2-silenced cells. In an animal study, pretreatment with DADS relieved Dox-induced albuminuria, increased catalase activity, and reduced the urinary 8-hydroxy-2’-deoxyguanosine level. In addition, DADS ameliorated the severity of glomerulosclerosis and suppressed expressions of fibrotic and inflammatory gene expressions. Our data indicate that DADS, a major component of garlic, showed protective effects of preventing the progression of Dox-induced nephropathy through enhancing Nrf2-mediated antioxidant activity. DADS, a normal constituent of the human diet, merits investigation as a potential antioxidant daily food supplement against free radical-mediated chronic diseases.
原文英語
頁(從 - 到)1040-1046
頁數7
期刊Food Science and Technology
39
發行號4
DOIs
出版狀態已發佈 - 十月 1 2019

ASJC Scopus subject areas

  • Biotechnology
  • Food Science

指紋 深入研究「The compound, diallyl disulfide, enriched in garlic, prevents the progressiodoxorubicin-induced nephropathy」主題。共同形成了獨特的指紋。

  • 引用此