The cerebellar development in chinese children-a study by voxel-based volume measurement of reconstructed 3D MRI scan

Kuan Hsun Wu, Chia Yuan Chen, Ein-Yiao Shen

研究成果: 雜誌貢獻文章

8 引文 斯高帕斯(Scopus)

摘要

Cerebellar disorder was frequently reported to have relation with structural brain volume alteration and/or morphology change. In dealing with such clinical situations, we need a convenient and noninvasive imaging tool to provide clinicians with a means of tracing developmental changes in the cerebellum. Herein, we present a new daily practice method for cerebellum imaging that uses a work station and a software program to process reconstructed 3D neuroimages after MRI scanning. In a 3-y period, 3D neuroimages reconstructed from MRI scans of 50 children aged 0.2-12.7 y were taken. The resulting images were then statistically analyzed against a growth curve. We observed a remarkable increase in the size of the cerebellum in the first 2 y of life. Furthermore, the unmyelinated cerebellum grew mainly between birth and 2 y of age in the postnatal stage. In contrast, the postnatal development of the brain mainly depended on the growth of myelinated cerebellum from birth through adolescence. This study presents basic data from a study of ethnic Chinese children's cerebellums using reconstructed 3D brain images. Based on the technique we introduce here, clinicians can evaluate the growth of the brain.
原文英語
頁(從 - 到)80-83
頁數4
期刊Pediatric Research
69
發行號1
DOIs
出版狀態已發佈 - 一月 2011

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

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