The surface of Ti6Al4V substrate was modified by two ways: micro-powder blasting and co-blast technique. Micro-powder blasting was done using Al 2 O 3 (of three different sizes) or SiC particles. Co-blast technique was done using the same particles co-blasted with hydroxyapatite (HA) particles. The morphology, roughness, deep impact and contact angle were used to characterise the surface modifications. The Ca/P atomic ratio was also determined by co-blast technique. Finally, the biocompatibility of Ti6Al4V substrate was investigated by surface modification in cell culture (osteoblast-like cell, MG63). The contact angle of Ti6Al4V substrate with surface modification is smaller than that without surface modification. The Ti6Al4V substrates by co-blast technique become more hydrophilic by co-blast technique and exhibit better cell proliferation.
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