The bidirectional association between oral cancer and esophageal cancer: A population-based study in Taiwan over a 28-year period

Kuan Der Lee, Ting Yao Wang, Chang Hsien Lu, Cih En Huang, Min Chi Chen

研究成果: 雜誌貢獻文章

2 引文 (Scopus)

摘要

Previous studies have revealed that patients with oral or esophageal cancer are at higher risk for subsequently developing a second primary malignancy. However, it remains to be determined what association exists between oral cancer and esophageal cancer particularly in Asian countries where squamous cell carcinoma is the predominant type of esophageal cancer. A population-based study was carried out in Taiwan, where the incidence rates of both oral and esophageal squamous cell carcinomas are high, to test the hypothesis that oral cancer or esophageal cancer predisposes an individual to developing the other form of cancer. Our results showed that patients with primary oral cancer (n=45,859) had ten times the risk of second esophageal cancer compared to the general population. Within the same cohort, the reciprocal risk of oral cancer as a second primary in primary esophageal cancer patients (n=16,658) was also increased seven-fold. The bidirectional relationship suggests common risk factors between these two cancers. The present study is not only the first population-based study in Asia to validate the reciprocal relationship between oral and esophageal squamous cell carcinomas, but also will aid in the appropriate selection of high-risk patients for a future follow-up surveillance program.
原文英語
頁(從 - 到)44567-44578
頁數12
期刊Oncotarget
8
發行號27
DOIs
出版狀態已發佈 - 2017

指紋

Mouth Neoplasms
Esophageal Neoplasms
Taiwan
Population
Second Primary Neoplasms
Squamous Cell Carcinoma
Neoplasms
Incidence

ASJC Scopus subject areas

  • Oncology

引用此文

The bidirectional association between oral cancer and esophageal cancer : A population-based study in Taiwan over a 28-year period. / Lee, Kuan Der; Wang, Ting Yao; Lu, Chang Hsien; Huang, Cih En; Chen, Min Chi.

於: Oncotarget, 卷 8, 編號 27, 2017, p. 44567-44578.

研究成果: 雜誌貢獻文章

Lee, Kuan Der ; Wang, Ting Yao ; Lu, Chang Hsien ; Huang, Cih En ; Chen, Min Chi. / The bidirectional association between oral cancer and esophageal cancer : A population-based study in Taiwan over a 28-year period. 於: Oncotarget. 2017 ; 卷 8, 編號 27. 頁 44567-44578.
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