The autosynthetic and solid extraction method developed on [F-18]flumazenil radiosynthesis

Jenn Tzong Chen, Kang Wei Chang, Yean Hung Tu, Wuu Jyh Lin

研究成果: 雜誌貢獻文章同行評審

1 引文 斯高帕斯(Scopus)

摘要

This study represents the newly developed autosynthetic and purification method for radiofluorinated flumazenil [18F]FMZ as the brain GABA/BZR receptor antagonist imaging agent. It represents a fast and convenient way to produce [18F]FMZ and is much easier to meet GMP compliance than preparative HPLC process. The process takes 45 minutes, decay corrected yield is 20-30%, and the radiochemical purity of the product is higher than 95%. The lipophilicity is a little higher partition coefficient with 1.49±0.12 which represents the high capability of penetrating the blood-brain barrier (BBB). An ex vivo study of this product bound to brain whole-hemisphere sections demonstrated complete inhibition of a BZR agonist which proved the capability of the newly developed solid extraction purification method can be applied in non-carrier added 18F-flumazenil preparation for further animal and clinical studies.
原文英語
頁(從 - 到)412-414
頁數3
期刊Journal of Labelled Compounds and Radiopharmaceuticals
53
發行號5-6
DOIs
出版狀態已發佈 - 五月 1 2010
對外發佈

ASJC Scopus subject areas

  • 分析化學
  • 生物化學
  • 放射學、核子醫學和影像學
  • 藥物發現
  • 光譜
  • 有機化學

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