The Aurora Kinases inhibitor VE-465 is a novel treatment for glioblastoma multiforme

Pei Ying Lee, Chi Long Chen, Zhong Zhe Lin, Ann Lii Cheng, Edmund I Tsuen Chen, Jacqueline Whang-Peng, Chi Ying F Huang

研究成果: 雜誌貢獻文章同行評審

9 引文 斯高帕斯(Scopus)

摘要

Glioblastoma multiforme (GBM) is one of the most common and aggressive types of primary brain tumor. After complete surgical resection combined with radiation and chemotherapy, approximately 10% of patients survive for more than 5 years. Therefore, a novel therapy for GBM is needed. Aurora-A (AURKA) plays important roles in cell cycle regulation, such as centrosome maturation, chromatic separation, bipolar spindle assembly, and mitotic entry. To investigate the effects of AURKA inhibition, three GBM cell lines, including GBM 8401, GBM 8901, and U87-MG cells, were treated with the AURKA inhibitor VE-465. Sensitivities to VE-465, as indicated by 50% inhibitory concentration values for GBM 8401, GBM 8901, and U87-MG cells, were 6, 25, and 19 nM, respectively. Additionally, colony formation of GBM 8401 and GBM 8901 cells was decreased after treatment with the VE-465. VE-465 treatment increased polyploidy and p53 protein expression, and inhibited cell growth in a caspase-independent manner. Taken together, these results suggest that the inhibition of AURKA by a small-molecule inhibitor may have potential to serve as a novel therapeutic approach for GBM.
原文英語
頁(從 - 到)326-335
頁數10
期刊Oncology
84
發行號6
DOIs
出版狀態已發佈 - 六月 2013

ASJC Scopus subject areas

  • 癌症研究
  • 腫瘤科

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