摘要

Purpose: Mild traumatic brain injury (mTBI) is a major public health concern. The apolipoprotein E (APOE) gene contains three polymorphisms, and the APOE4 polymorphism may affect several physiological states, such as the recovery from mTBI as well as sleep. This study aims to investigate the association between APOE4 with the recovery of sleep disturbance after mTBI. Methods: From May 2012 to Aug 2015, 189 mTBI patients completed baseline (1st week post-mTBI) and follow-up (6th week post-mTBI) sleep assessments that involved using the Pittsburgh Sleep Quality Index (PSQI). APOE genotypes were determined by sequencing the products of polymerase chain reaction from genomic DNA. Statistical analyses were performed using the Wilcox signed-rank or chi-square test. Results: Thirty-five (18.5%) participants were APOE4 carriers. At baseline, the demographic data and the severity of sleep disturbance were similar in both groups. APOE4 carriers demonstrated significant improvement in the overall PSQI score (8.34±3.9 at baseline and 7.43±3.99 at follow-up, p = 0.05) and scores of several PSQI subscales, including sleep disturbance, sleep latency, daytime dysfunction caused by sleepiness, and overall sleep quality, which was similar to APOE4 noncarriers. Conclusion: APOE4 is not associated with the recovery of sleep disturbance after mTBI.
原文英語
頁(從 - 到)13-19
頁數7
期刊Acta Neurologica Taiwanica
26
發行號1
出版狀態已發佈 - 2017

指紋

Brain Concussion
Apolipoprotein E4
Sleep
Alleles
Apolipoproteins E
Chi-Square Distribution

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology

引用此文

@article{a226ba40e8b74e0d8119258e6ab107bb,
title = "The association of Apolipoprotein E allele 4 polymorphism with the recovery of sleep disturbance after mild traumatic brain injury",
abstract = "Purpose: Mild traumatic brain injury (mTBI) is a major public health concern. The apolipoprotein E (APOE) gene contains three polymorphisms, and the APOE4 polymorphism may affect several physiological states, such as the recovery from mTBI as well as sleep. This study aims to investigate the association between APOE4 with the recovery of sleep disturbance after mTBI. Methods: From May 2012 to Aug 2015, 189 mTBI patients completed baseline (1st week post-mTBI) and follow-up (6th week post-mTBI) sleep assessments that involved using the Pittsburgh Sleep Quality Index (PSQI). APOE genotypes were determined by sequencing the products of polymerase chain reaction from genomic DNA. Statistical analyses were performed using the Wilcox signed-rank or chi-square test. Results: Thirty-five (18.5{\%}) participants were APOE4 carriers. At baseline, the demographic data and the severity of sleep disturbance were similar in both groups. APOE4 carriers demonstrated significant improvement in the overall PSQI score (8.34±3.9 at baseline and 7.43±3.99 at follow-up, p = 0.05) and scores of several PSQI subscales, including sleep disturbance, sleep latency, daytime dysfunction caused by sleepiness, and overall sleep quality, which was similar to APOE4 noncarriers. Conclusion: APOE4 is not associated with the recovery of sleep disturbance after mTBI.",
keywords = "Apolipoprotein E4, Mild traumatic brain injury, Sleep",
author = "Lee, {Hsun Hua} and Yeh, {Chun Ting} and Ou, {Ju Chi} and Ma, {Hon Ping} and Chen, {Kai Yun} and Chang, {Cheng Fu} and Lai, {Jing Huei} and Liao, {Kuo Hsing} and Lin, {Chien Min} and Lin, {Shu Yu} and Dean Wu and Huang, {Yao Hsien} and Hu, {Chaur Jong} and Hong, {Chien Tai}",
year = "2017",
language = "English",
volume = "26",
pages = "13--19",
journal = "Acta Neurologica Taiwanica",
issn = "1019-6099",
publisher = "Taiwan Neurological Society",
number = "1",

}

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T1 - The association of Apolipoprotein E allele 4 polymorphism with the recovery of sleep disturbance after mild traumatic brain injury

AU - Lee, Hsun Hua

AU - Yeh, Chun Ting

AU - Ou, Ju Chi

AU - Ma, Hon Ping

AU - Chen, Kai Yun

AU - Chang, Cheng Fu

AU - Lai, Jing Huei

AU - Liao, Kuo Hsing

AU - Lin, Chien Min

AU - Lin, Shu Yu

AU - Wu, Dean

AU - Huang, Yao Hsien

AU - Hu, Chaur Jong

AU - Hong, Chien Tai

PY - 2017

Y1 - 2017

N2 - Purpose: Mild traumatic brain injury (mTBI) is a major public health concern. The apolipoprotein E (APOE) gene contains three polymorphisms, and the APOE4 polymorphism may affect several physiological states, such as the recovery from mTBI as well as sleep. This study aims to investigate the association between APOE4 with the recovery of sleep disturbance after mTBI. Methods: From May 2012 to Aug 2015, 189 mTBI patients completed baseline (1st week post-mTBI) and follow-up (6th week post-mTBI) sleep assessments that involved using the Pittsburgh Sleep Quality Index (PSQI). APOE genotypes were determined by sequencing the products of polymerase chain reaction from genomic DNA. Statistical analyses were performed using the Wilcox signed-rank or chi-square test. Results: Thirty-five (18.5%) participants were APOE4 carriers. At baseline, the demographic data and the severity of sleep disturbance were similar in both groups. APOE4 carriers demonstrated significant improvement in the overall PSQI score (8.34±3.9 at baseline and 7.43±3.99 at follow-up, p = 0.05) and scores of several PSQI subscales, including sleep disturbance, sleep latency, daytime dysfunction caused by sleepiness, and overall sleep quality, which was similar to APOE4 noncarriers. Conclusion: APOE4 is not associated with the recovery of sleep disturbance after mTBI.

AB - Purpose: Mild traumatic brain injury (mTBI) is a major public health concern. The apolipoprotein E (APOE) gene contains three polymorphisms, and the APOE4 polymorphism may affect several physiological states, such as the recovery from mTBI as well as sleep. This study aims to investigate the association between APOE4 with the recovery of sleep disturbance after mTBI. Methods: From May 2012 to Aug 2015, 189 mTBI patients completed baseline (1st week post-mTBI) and follow-up (6th week post-mTBI) sleep assessments that involved using the Pittsburgh Sleep Quality Index (PSQI). APOE genotypes were determined by sequencing the products of polymerase chain reaction from genomic DNA. Statistical analyses were performed using the Wilcox signed-rank or chi-square test. Results: Thirty-five (18.5%) participants were APOE4 carriers. At baseline, the demographic data and the severity of sleep disturbance were similar in both groups. APOE4 carriers demonstrated significant improvement in the overall PSQI score (8.34±3.9 at baseline and 7.43±3.99 at follow-up, p = 0.05) and scores of several PSQI subscales, including sleep disturbance, sleep latency, daytime dysfunction caused by sleepiness, and overall sleep quality, which was similar to APOE4 noncarriers. Conclusion: APOE4 is not associated with the recovery of sleep disturbance after mTBI.

KW - Apolipoprotein E4

KW - Mild traumatic brain injury

KW - Sleep

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VL - 26

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EP - 19

JO - Acta Neurologica Taiwanica

JF - Acta Neurologica Taiwanica

SN - 1019-6099

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