The association between single-nucleotide polymorphisms of ORAI1 gene and breast cancer in a Taiwanese population

Wei Chiao Chang, Peng Yeong Woon, Yu Wen Hsu, Shengyu Yang, Yi Ching Chiu, Ming Feng Hou

研究成果: 雜誌貢獻文章

6 引文 (Scopus)

摘要

Background. Breast cancer is the most common malignancy in women. There is increasing evidence suggesting that ORAI1, components of store-operated calcium channel, play a pivotal role in breast cancer progression and metastasis. Methods. A total of 384 female patients with breast cancer were included in this study. We selected five representative tagging ORAI1 SNPs from HapMap database with minimum allele frequency (MAF) ≥ 10%. Genotyping was performed using TaqMan allelic discrimination assay. Chi-square (X2) test was used to analyze statistical differences among control and patient groups in genotype and allelic frequencies. Results. Two of the ORAI1 SNPs (rs12320939 and rs12313273) were associated with estrogen receptors positive in breast cancer patients under the recessive model. When the Bonferroni correction was performed, the significance still existed. In addition, rs12320939 also associated with the lymph nodal involvement. Conclusion. We showed that genetic polymorphisms of ORAI1 associated strongly with lymph nodal involvement and estrogen receptors (ERs) positive breast cancer patients in a Taiwanese population.

原文英語
文章編號916587
期刊Scientific World Journal
2012
DOIs
出版狀態已發佈 - 2012

指紋

Polymorphism
Estrogen Receptors
Single Nucleotide Polymorphism
cancer
polymorphism
Nucleotides
Genes
Association reactions
Breast Neoplasms
gene
Calcium Channels
Population
Lymph
Assays
HapMap Project
tagging
Genetic Polymorphisms
Chi-Square Distribution
Gene Frequency
allele

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Environmental Science(all)
  • Medicine(all)

引用此文

The association between single-nucleotide polymorphisms of ORAI1 gene and breast cancer in a Taiwanese population. / Chang, Wei Chiao; Woon, Peng Yeong; Hsu, Yu Wen; Yang, Shengyu; Chiu, Yi Ching; Hou, Ming Feng.

於: Scientific World Journal, 卷 2012, 916587, 2012.

研究成果: 雜誌貢獻文章

Chang, Wei Chiao ; Woon, Peng Yeong ; Hsu, Yu Wen ; Yang, Shengyu ; Chiu, Yi Ching ; Hou, Ming Feng. / The association between single-nucleotide polymorphisms of ORAI1 gene and breast cancer in a Taiwanese population. 於: Scientific World Journal. 2012 ; 卷 2012.
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abstract = "Background. Breast cancer is the most common malignancy in women. There is increasing evidence suggesting that ORAI1, components of store-operated calcium channel, play a pivotal role in breast cancer progression and metastasis. Methods. A total of 384 female patients with breast cancer were included in this study. We selected five representative tagging ORAI1 SNPs from HapMap database with minimum allele frequency (MAF) ≥ 10{\%}. Genotyping was performed using TaqMan allelic discrimination assay. Chi-square (X2) test was used to analyze statistical differences among control and patient groups in genotype and allelic frequencies. Results. Two of the ORAI1 SNPs (rs12320939 and rs12313273) were associated with estrogen receptors positive in breast cancer patients under the recessive model. When the Bonferroni correction was performed, the significance still existed. In addition, rs12320939 also associated with the lymph nodal involvement. Conclusion. We showed that genetic polymorphisms of ORAI1 associated strongly with lymph nodal involvement and estrogen receptors (ERs) positive breast cancer patients in a Taiwanese population.",
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AU - Chiu, Yi Ching

AU - Hou, Ming Feng

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N2 - Background. Breast cancer is the most common malignancy in women. There is increasing evidence suggesting that ORAI1, components of store-operated calcium channel, play a pivotal role in breast cancer progression and metastasis. Methods. A total of 384 female patients with breast cancer were included in this study. We selected five representative tagging ORAI1 SNPs from HapMap database with minimum allele frequency (MAF) ≥ 10%. Genotyping was performed using TaqMan allelic discrimination assay. Chi-square (X2) test was used to analyze statistical differences among control and patient groups in genotype and allelic frequencies. Results. Two of the ORAI1 SNPs (rs12320939 and rs12313273) were associated with estrogen receptors positive in breast cancer patients under the recessive model. When the Bonferroni correction was performed, the significance still existed. In addition, rs12320939 also associated with the lymph nodal involvement. Conclusion. We showed that genetic polymorphisms of ORAI1 associated strongly with lymph nodal involvement and estrogen receptors (ERs) positive breast cancer patients in a Taiwanese population.

AB - Background. Breast cancer is the most common malignancy in women. There is increasing evidence suggesting that ORAI1, components of store-operated calcium channel, play a pivotal role in breast cancer progression and metastasis. Methods. A total of 384 female patients with breast cancer were included in this study. We selected five representative tagging ORAI1 SNPs from HapMap database with minimum allele frequency (MAF) ≥ 10%. Genotyping was performed using TaqMan allelic discrimination assay. Chi-square (X2) test was used to analyze statistical differences among control and patient groups in genotype and allelic frequencies. Results. Two of the ORAI1 SNPs (rs12320939 and rs12313273) were associated with estrogen receptors positive in breast cancer patients under the recessive model. When the Bonferroni correction was performed, the significance still existed. In addition, rs12320939 also associated with the lymph nodal involvement. Conclusion. We showed that genetic polymorphisms of ORAI1 associated strongly with lymph nodal involvement and estrogen receptors (ERs) positive breast cancer patients in a Taiwanese population.

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