The association between serum vitamin D level and risk and prognosis of melanoma: a systematic review and meta-analysis

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16 引文 斯高帕斯(Scopus)

摘要

Background: Vitamin D has antineoplastic effects, but the synthesis of vitamin D requires ultraviolet radiation, a known risk factor for melanoma. Objective: To investigate the correlations between serum vitamin D levels and risk and prognosis of melanoma. Methods: A systematic review and meta-analysis were conducted. Online databases were searched on 31 Oct 2018. Results: Twenty-five studies with a total of 11166 patients with melanoma were included. There was no significant difference in serum vitamin D levels between patients with melanoma and controls [standardized mean difference (SMD), −0.185; 95% confidence interval (CI), −0.533 to 0.162]. However, the prevalence of vitamin D deficiency was significantly higher in patients with melanoma than that in controls (odds ratio, 2.115; 95% CI, 1.151–3.885). In terms of prognosis, serum vitamin D levels were significantly higher in melanoma patients with lower Breslow thickness (≦1 vs. >1 mm: SMD, 0.243; 95% CI, 0.160–0.327). Moreover, melanoma patients with lower vitamin D levels had a significantly higher mortality rate (hazard ratio, 1.558; 95% CI, 1.258–1.931). Conclusions: Vitamin D deficiency is associated with higher Breslow thickness and mortality in melanoma patients.

原文英語
頁(從 - 到)1722-1729
頁數8
期刊Journal of the European Academy of Dermatology and Venereology
34
發行號8
DOIs
出版狀態已發佈 - 8月 1 2020

ASJC Scopus subject areas

  • 皮膚科
  • 傳染性疾病

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