Background: Multiple sclerosis (MS) is the most common inflammatory demyelinating disease of the central nervous system. Few studies focused on the relationship between septicemia and MS. Aim: To evaluate the potential impact of septicemia on risk for MS. Design: Two cohorts of patients with septicemia and without septicemia were followed up for the occurrence of MS. Methods: Patients of 482 790 with septicemia was enrolled from the National Health Insurance Research Database between 2001 and 2011 as the study group to match the 1 892 820 individuals, as the control group, by age and gender. Incidence of MS in both groups was calculated. Cox proportional-hazards regressions were performed for investigating hazard ratios (HR) for MS between groups. Results: Septicemia patients had a 3.06-fold (95% CI: 2.16-4.32, P < 0.001) greater risk of developing MS than the matched group. In addition, higher severity of septicemia was associated with higher risk of developing MS (moderate: HR ¼ 4.03, 95% CI: 2.53-6.45, P < 0.001; severe: HR ¼ 11.1, 95% CI: 7.01-17.7, P < 0.001). Similar results also occurred in both male and female patients with septicemia (male: HR ¼ 4.06, 95% CI: 2.17-7.58, P < 0.001; female: HR ¼ 2.72, 95% CI: 1.79-4.11, P < 0.001). Patients without counterpart comorbidities had a significantly higher risk of MS than the controlled group (HR ¼ 3.02, 95% CI: 2.10-4.35, P < 0.001). Conclusion: The results indicated septicemia is linked to an increased risk for MS. Aggressively preventing and treating septicemia may be warranted for one of precautionary strategies of MS.
ASJC Scopus subject areas
- 醫藥 (全部)