The association between plasma selenium and chronic kidney disease related to lead, cadmium and arsenic exposure in a Taiwanese population

研究成果: 雜誌貢獻文章

1 引文 (Scopus)

摘要

This study aimed to determine the interaction of red blood cell cadmium and lead, total urinary arsenic, and plasma selenium in chronic kidney disease (CKD). We recruited 220 CKD patients as well as 438 gender- and age-matched controls, and we defined CKD as <60 mL/min/1.73 m 2 estimated glomerular filtration rate (eGFR)for three or more consecutive months. Plasma selenium and red blood cell cadmium and lead concentrations were measured by ICP-MS. Urinary arsenic species were determined via HPLC-HG-AAS and were summed to determine the total urinary arsenic concentration. Plasma selenium was positively correlated to eGFR, and subjects with high plasma selenium levels (>243.90 μg/L)had a significantly lower odds ratio (OR)and 95% confidence interval (CI)(0.23, 0.13–0.42)for CKD compared to those with low plasma selenium levels (≤ 196.70 μg/L). High plasma selenium and low red blood cell cadmium or lead concentrations interacted to decrease the OR and 95% CI for CKD (0.12, 0.06–0.26; 0.09, 0.04–0.19). High plasma selenium and low red blood cell lead levels also interacted to increase the eGFR (20.70, 15.56–26.01 mL/min/1.73 m 2 ). This study is the first to suggest that selenium modifies the eGFR and OR in CKD induced by environmental toxicants.

原文英語
頁(從 - 到)224-232
頁數9
期刊Journal of Hazardous Materials
375
DOIs
出版狀態已發佈 - 八月 5 2019

指紋

Selenium
Arsenic
Cadmium
selenium
Chronic Renal Insufficiency
arsenic
cadmium
Plasmas
plasma
Glomerular Filtration Rate
Population
Blood
Erythrocytes
blood
Cells
Lead
Odds Ratio
confidence interval
Confidence Intervals
exposure

ASJC Scopus subject areas

  • Environmental Engineering
  • Environmental Chemistry
  • Waste Management and Disposal
  • Pollution
  • Health, Toxicology and Mutagenesis

引用此文

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title = "The association between plasma selenium and chronic kidney disease related to lead, cadmium and arsenic exposure in a Taiwanese population",
abstract = "This study aimed to determine the interaction of red blood cell cadmium and lead, total urinary arsenic, and plasma selenium in chronic kidney disease (CKD). We recruited 220 CKD patients as well as 438 gender- and age-matched controls, and we defined CKD as <60 mL/min/1.73 m 2 estimated glomerular filtration rate (eGFR)for three or more consecutive months. Plasma selenium and red blood cell cadmium and lead concentrations were measured by ICP-MS. Urinary arsenic species were determined via HPLC-HG-AAS and were summed to determine the total urinary arsenic concentration. Plasma selenium was positively correlated to eGFR, and subjects with high plasma selenium levels (>243.90 μg/L)had a significantly lower odds ratio (OR)and 95{\%} confidence interval (CI)(0.23, 0.13–0.42)for CKD compared to those with low plasma selenium levels (≤ 196.70 μg/L). High plasma selenium and low red blood cell cadmium or lead concentrations interacted to decrease the OR and 95{\%} CI for CKD (0.12, 0.06–0.26; 0.09, 0.04–0.19). High plasma selenium and low red blood cell lead levels also interacted to increase the eGFR (20.70, 15.56–26.01 mL/min/1.73 m 2 ). This study is the first to suggest that selenium modifies the eGFR and OR in CKD induced by environmental toxicants.",
keywords = "Arsenic, Arsenic methylation capacity, Cadmium, Chronic kidney disease, Lead, Selenium",
author = "Wu, {Chih Yin} and Wong, {Chung Shun} and Chung, {Chi Jung} and Wu, {Mei Yi} and Huang, {Ya Li} and Ao, {Pui Lam} and Lin, {Yuh Feng} and Lin, {Ying Chin} and Shiue, {Horng Sheng} and Su, {Chien Tien} and Chen, {Hsi Hsien} and Hsueh, {Yu Mei}",
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T1 - The association between plasma selenium and chronic kidney disease related to lead, cadmium and arsenic exposure in a Taiwanese population

AU - Wu, Chih Yin

AU - Wong, Chung Shun

AU - Chung, Chi Jung

AU - Wu, Mei Yi

AU - Huang, Ya Li

AU - Ao, Pui Lam

AU - Lin, Yuh Feng

AU - Lin, Ying Chin

AU - Shiue, Horng Sheng

AU - Su, Chien Tien

AU - Chen, Hsi Hsien

AU - Hsueh, Yu Mei

PY - 2019/8/5

Y1 - 2019/8/5

N2 - This study aimed to determine the interaction of red blood cell cadmium and lead, total urinary arsenic, and plasma selenium in chronic kidney disease (CKD). We recruited 220 CKD patients as well as 438 gender- and age-matched controls, and we defined CKD as <60 mL/min/1.73 m 2 estimated glomerular filtration rate (eGFR)for three or more consecutive months. Plasma selenium and red blood cell cadmium and lead concentrations were measured by ICP-MS. Urinary arsenic species were determined via HPLC-HG-AAS and were summed to determine the total urinary arsenic concentration. Plasma selenium was positively correlated to eGFR, and subjects with high plasma selenium levels (>243.90 μg/L)had a significantly lower odds ratio (OR)and 95% confidence interval (CI)(0.23, 0.13–0.42)for CKD compared to those with low plasma selenium levels (≤ 196.70 μg/L). High plasma selenium and low red blood cell cadmium or lead concentrations interacted to decrease the OR and 95% CI for CKD (0.12, 0.06–0.26; 0.09, 0.04–0.19). High plasma selenium and low red blood cell lead levels also interacted to increase the eGFR (20.70, 15.56–26.01 mL/min/1.73 m 2 ). This study is the first to suggest that selenium modifies the eGFR and OR in CKD induced by environmental toxicants.

AB - This study aimed to determine the interaction of red blood cell cadmium and lead, total urinary arsenic, and plasma selenium in chronic kidney disease (CKD). We recruited 220 CKD patients as well as 438 gender- and age-matched controls, and we defined CKD as <60 mL/min/1.73 m 2 estimated glomerular filtration rate (eGFR)for three or more consecutive months. Plasma selenium and red blood cell cadmium and lead concentrations were measured by ICP-MS. Urinary arsenic species were determined via HPLC-HG-AAS and were summed to determine the total urinary arsenic concentration. Plasma selenium was positively correlated to eGFR, and subjects with high plasma selenium levels (>243.90 μg/L)had a significantly lower odds ratio (OR)and 95% confidence interval (CI)(0.23, 0.13–0.42)for CKD compared to those with low plasma selenium levels (≤ 196.70 μg/L). High plasma selenium and low red blood cell cadmium or lead concentrations interacted to decrease the OR and 95% CI for CKD (0.12, 0.06–0.26; 0.09, 0.04–0.19). High plasma selenium and low red blood cell lead levels also interacted to increase the eGFR (20.70, 15.56–26.01 mL/min/1.73 m 2 ). This study is the first to suggest that selenium modifies the eGFR and OR in CKD induced by environmental toxicants.

KW - Arsenic

KW - Arsenic methylation capacity

KW - Cadmium

KW - Chronic kidney disease

KW - Lead

KW - Selenium

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