The association between hypoxia inducible factor-1alpha gene polymorphisms and increased susceptibility to oral cancer

Mu Kuan Chen, Hui Ling Chiou, Shih Chi Su, Tsung Te Chung, Hsien Chun Tseng, Hsiu Ting Tsai, Shun Fa Yang

研究成果: 雜誌貢獻文章同行評審

46 引文 斯高帕斯(Scopus)

摘要

The aim of this study was to estimate the relations between hypoxia inducible factor-1α (HIF-1α) gene polymorphisms, C1772T and G1790A, to the susceptibility and clinicopathological status of oral cancer. A total of 521 subjects, including 347 controls and 174 oral cancer patients, were recruited in this study and subjected to polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) to analyze the impact of these two polymorphic variants on oral cancer. A significant association between oral cancer susceptibility and G1790A polymorphism was demonstrated since individuals with heterozygotes, that is GA, had a higher risk for oral cancer, compared to GG genotypes after adjusting for other confounders (AOR = 3.31; 95%CI = 1.27-8.61). Compared to individuals with both C1772C and G1790G homozygotes, individuals with at least one of either C1772T or G1790A of HIF-1α gene had a risk of 2.17-folds (95% CI = 1.0-4.75) to develop oral cancer. Moreover, results also revealed the presence of synergistic effect between gene polymorphisms of HIF-1α and environmental risk factors, such as tobacco and betel nut consumptions while there was no significant association between HIF-1α gene polymorphism and clinicopathological parameters of oral cancer. Genetic polymorphism, including C1772T and G1790A, of HIF-1α is an important factor for the susceptibility to oral cancer.
原文英語
頁(從 - 到)e222-e226
期刊Oral Oncology
45
發行號12
DOIs
出版狀態已發佈 - 十二月 2009
對外發佈Yes

ASJC Scopus subject areas

  • Oral Surgery
  • Oncology
  • Cancer Research

指紋 深入研究「The association between hypoxia inducible factor-1alpha gene polymorphisms and increased susceptibility to oral cancer」主題。共同形成了獨特的指紋。

引用此