摘要

Background: Brain-derived neurotrophic factor (BDNF) is one of the most abundant neurotrophins in the adult brain, and it plays important roles in modulating synaptic plasticity and synaptogenesis. This study attempted to elucidate the role of the BDNF variant rs6265 in emotional symptoms following mild traumatic brain injury (mTBI). Methods: To investigate the association between BDNF Val66Met polymorphism (rs6265) and emotional symptoms in mTBI patients, we recruited 192 mTBI patients and evaluated their Beck Anxiety Inventory (BAI) and Beck Depression Inventory (BDI) scores in the first and sixth week after mTBI. Results: The patients carrying the T allele of rs6265 had significantly higher BAI scores in the first week following mTBI. In addition, the patients carrying the T allele also showed higher scores of BDI in the first week. In the gender-specific subgroup analysis, the male patients carrying the T allele of rs6265 had higher scores of both BAI and BDI in the first and sixth week. Meanwhile, female patients carrying the T allele also had significantly higher scores of BDI in the first week following mTBI. Conclusions: This study provides evidence for the association between the BDNF variant rs6265 and emotional symptoms following mTBI.
原文英語
文章編號13
期刊BMC Medical Genetics
19
發行號1
DOIs
出版狀態已發佈 - 一月 22 2018

指紋

Brain Concussion
Brain-Derived Neurotrophic Factor
Equipment and Supplies
Alleles
Depression
Anxiety
Neuronal Plasticity
Nerve Growth Factors
Brain

ASJC Scopus subject areas

  • Genetics
  • Genetics(clinical)

引用此文

The association between BDNF Val66Met polymorphism and emotional symptoms after mild traumatic brain injury. / Wang, Yu Jia; Chen, Kai Yun; Kuo, Li Na; Wang, Wen Chang; Hsu, Yu Wen; Wong, Henry Sung Ching; Lin, Chien Min; Liao, Kuo Hsing; Zhang, Yan Feng; Chiang, Yung Hsiao; Chang, Wei Chiao.

於: BMC Medical Genetics, 卷 19, 編號 1, 13, 22.01.2018.

研究成果: 雜誌貢獻文章

@article{15c99f5818f440e39240a8382c716914,
title = "The association between BDNF Val66Met polymorphism and emotional symptoms after mild traumatic brain injury",
abstract = "Background: Brain-derived neurotrophic factor (BDNF) is one of the most abundant neurotrophins in the adult brain, and it plays important roles in modulating synaptic plasticity and synaptogenesis. This study attempted to elucidate the role of the BDNF variant rs6265 in emotional symptoms following mild traumatic brain injury (mTBI). Methods: To investigate the association between BDNF Val66Met polymorphism (rs6265) and emotional symptoms in mTBI patients, we recruited 192 mTBI patients and evaluated their Beck Anxiety Inventory (BAI) and Beck Depression Inventory (BDI) scores in the first and sixth week after mTBI. Results: The patients carrying the T allele of rs6265 had significantly higher BAI scores in the first week following mTBI. In addition, the patients carrying the T allele also showed higher scores of BDI in the first week. In the gender-specific subgroup analysis, the male patients carrying the T allele of rs6265 had higher scores of both BAI and BDI in the first and sixth week. Meanwhile, female patients carrying the T allele also had significantly higher scores of BDI in the first week following mTBI. Conclusions: This study provides evidence for the association between the BDNF variant rs6265 and emotional symptoms following mTBI.",
keywords = "Anxiety, Brain-derived neurotrophic factor, Depression, Genetic polymorphism, Mild traumatic brain injury",
author = "Wang, {Yu Jia} and Chen, {Kai Yun} and Kuo, {Li Na} and Wang, {Wen Chang} and Hsu, {Yu Wen} and Wong, {Henry Sung Ching} and Lin, {Chien Min} and Liao, {Kuo Hsing} and Zhang, {Yan Feng} and Chiang, {Yung Hsiao} and Chang, {Wei Chiao}",
year = "2018",
month = "1",
day = "22",
doi = "10.1186/s12881-017-0518-0",
language = "English",
volume = "19",
journal = "BMC Medical Genetics",
issn = "1471-2350",
publisher = "BioMed Central",
number = "1",

}

TY - JOUR

T1 - The association between BDNF Val66Met polymorphism and emotional symptoms after mild traumatic brain injury

AU - Wang, Yu Jia

AU - Chen, Kai Yun

AU - Kuo, Li Na

AU - Wang, Wen Chang

AU - Hsu, Yu Wen

AU - Wong, Henry Sung Ching

AU - Lin, Chien Min

AU - Liao, Kuo Hsing

AU - Zhang, Yan Feng

AU - Chiang, Yung Hsiao

AU - Chang, Wei Chiao

PY - 2018/1/22

Y1 - 2018/1/22

N2 - Background: Brain-derived neurotrophic factor (BDNF) is one of the most abundant neurotrophins in the adult brain, and it plays important roles in modulating synaptic plasticity and synaptogenesis. This study attempted to elucidate the role of the BDNF variant rs6265 in emotional symptoms following mild traumatic brain injury (mTBI). Methods: To investigate the association between BDNF Val66Met polymorphism (rs6265) and emotional symptoms in mTBI patients, we recruited 192 mTBI patients and evaluated their Beck Anxiety Inventory (BAI) and Beck Depression Inventory (BDI) scores in the first and sixth week after mTBI. Results: The patients carrying the T allele of rs6265 had significantly higher BAI scores in the first week following mTBI. In addition, the patients carrying the T allele also showed higher scores of BDI in the first week. In the gender-specific subgroup analysis, the male patients carrying the T allele of rs6265 had higher scores of both BAI and BDI in the first and sixth week. Meanwhile, female patients carrying the T allele also had significantly higher scores of BDI in the first week following mTBI. Conclusions: This study provides evidence for the association between the BDNF variant rs6265 and emotional symptoms following mTBI.

AB - Background: Brain-derived neurotrophic factor (BDNF) is one of the most abundant neurotrophins in the adult brain, and it plays important roles in modulating synaptic plasticity and synaptogenesis. This study attempted to elucidate the role of the BDNF variant rs6265 in emotional symptoms following mild traumatic brain injury (mTBI). Methods: To investigate the association between BDNF Val66Met polymorphism (rs6265) and emotional symptoms in mTBI patients, we recruited 192 mTBI patients and evaluated their Beck Anxiety Inventory (BAI) and Beck Depression Inventory (BDI) scores in the first and sixth week after mTBI. Results: The patients carrying the T allele of rs6265 had significantly higher BAI scores in the first week following mTBI. In addition, the patients carrying the T allele also showed higher scores of BDI in the first week. In the gender-specific subgroup analysis, the male patients carrying the T allele of rs6265 had higher scores of both BAI and BDI in the first and sixth week. Meanwhile, female patients carrying the T allele also had significantly higher scores of BDI in the first week following mTBI. Conclusions: This study provides evidence for the association between the BDNF variant rs6265 and emotional symptoms following mTBI.

KW - Anxiety

KW - Brain-derived neurotrophic factor

KW - Depression

KW - Genetic polymorphism

KW - Mild traumatic brain injury

UR - http://www.scopus.com/inward/record.url?scp=85040861366&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85040861366&partnerID=8YFLogxK

U2 - 10.1186/s12881-017-0518-0

DO - 10.1186/s12881-017-0518-0

M3 - Article

AN - SCOPUS:85040861366

VL - 19

JO - BMC Medical Genetics

JF - BMC Medical Genetics

SN - 1471-2350

IS - 1

M1 - 13

ER -