The association between arsenic exposure from drinking water and arterial embolism and thrombosis in Northeastern Taiwan: Preliminary results

Ling I. Hsu, Chien Jen Chen, Hung Yi Chiou

研究成果: 書貢獻/報告類型會議貢獻

摘要

Arsenic exposure is an important public health issue worldwide. However, the association of arsenic exposure with diverse health effects at low-to-moderate level remains to be elucidated. The aim of this study is to elucidate the dose-response relationship between ingested arsenic and vascular occlusions for low-to-moderate level. A total of 7,359 residents in northeastern arseniasis-endemic areas in Taiwan were followed from 1998 to 2009. The disease status of each subject was ascertained through linkage with computerized Taiwan National Health Insurance (NHI) database. Cox regression analysis was used to determine the hazard ratio of the disease associated with arsenic concentration in well water. There were 267 newly diagnosed arterial embolism and thrombosis cases during a follow-up period of 76,180 person-years. The crude incidence rate (per 10,000 person-years) was 249, 375, 320, 467, 449 and 496 respectively in arsenic level of ≤ 10.0, 10.1-25.0, 25.0-50.0, 50.1-100.0, 100.1-400.0 and > 400.0 μg/L. The hazard ratio was 1.55 (95% confidence interval (CI), 1.02-2.36), 1.34 (95% CI, 0.87-2.08), 1.76 (95% CI, 1.18-2.70), 1.77 (95% CI, 1.19-2.62) and 2.23 (95% CI, 1.37-3.64) in arsenic level from 10.1-25.0 to >400.0 when compared to arsenic level ≤ 10.0 μg/L after adjustment of age, sex, education level, cigarette smoking, hypertension, diabetes and hyperlipidemia. We concluded that there was a monotonous trend between arsenic concentration in well water and risk of arterial embolism and thrombosis. The significant increased disease risk can be observed in arsenic level as low as 10.1-25.0 μg/L.

原文英語
主出版物標題Understanding the Geological and Medical Interface of Arsenic, As 2012 - 4th International Congress: Arsenic in the Environment
頁面153-154
頁數2
出版狀態已發佈 - 2012
事件4th International Congress on Arsenic in the Environment, As 2012 - Cairns, QLD, 澳大利亚
持續時間: 七月 22 2012七月 27 2012

其他

其他4th International Congress on Arsenic in the Environment, As 2012
國家澳大利亚
城市Cairns, QLD
期間7/22/127/27/12

ASJC Scopus subject areas

  • Environmental Chemistry
  • Pollution

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  • 引用此

    Hsu, L. I., Chen, C. J., & Chiou, H. Y. (2012). The association between arsenic exposure from drinking water and arterial embolism and thrombosis in Northeastern Taiwan: Preliminary results. 於 Understanding the Geological and Medical Interface of Arsenic, As 2012 - 4th International Congress: Arsenic in the Environment (頁 153-154)