The application of a random effects model to censored twin data

I. Chao Liu, Ronghui Xu, Deborah L. Blacker, Garrett Fitzmaurice, Michael J. Lyons, Ming T. Tsuang

研究成果: 雜誌貢獻文章同行評審

5 引文 斯高帕斯(Scopus)

摘要

The authors propose a random effects model to analyze the latent genetic and environmental effects on determining censored outcomes in twin studies. In this model, six normally distributed random effects are used to describe the correlation within twin pairs. The authors employ a Monte Carlo Expectation-Maximization approach for obtaining maximum likelihood estimates of fixed effects and the variances of random effects. The variances of the random effects are reparameterized to be equivalent to genetic and environmental effects in traditional twin models. The authors illustrate this model using data from the Vietnam Era Twin Registry to explore the magnitude of the genetic influence on twin similarity for the age of onset of alcohol abuse. Our results show genetic factors contribute about one third of twin similarity in the age of onset of alcohol abuse in male twins. The application of this model to twin data is discussed.

原文英語
頁(從 - 到)781-789
頁數9
期刊Behavior Genetics
35
發行號6
DOIs
出版狀態已發佈 - 11月 2005
對外發佈

ASJC Scopus subject areas

  • 遺傳學
  • 遺傳學(臨床)
  • 行為神經科學
  • 心理學(全部)

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