The antiplatelet activity of tetramethylpyrazine is mediated through activation of NO synthase

Joen Rong Sheu, Ya Chen Kan, Wei Chun Hung, Chien-Huang Lin, Mao Hsiung Yen

研究成果: 雜誌貢獻文章

50 引文 (Scopus)

摘要

Tetramethylpyrazine (TMPZ) is an active ingredient of a Chinese herbal medicine (Ligusticum wallichii Franchat). In this study, TMPZ (50-200 μM) significantly increased production of nitrate and cyclic GMP in human platelets within a 15-min incubation period. TMPZ concentration-dependently inhibited intracellular Ca2+ mobilization in human platelets stimulated by collagen (5 μg/ml). Furthermore, TMPZ concentration (50 and 200 μM)- and time (15 and 30 min)-dependently triggered endothelial-type constitutive nitric oxide synthase (ecNOS) protein expression in human platelets. These results indicated that TMPZ at micromolar concentrations stimulated nitric oxide production in human platelets via a novel mechanism that activated ecNOS protein expression. (C) 2000 Elsevier Science Inc.
原文英語
頁(從 - 到)937-947
頁數11
期刊Life Sciences
67
發行號8
DOIs
出版狀態已發佈 - 七月 14 2000

指紋

Nitric Oxide Synthase
Platelets
Chemical activation
Blood Platelets
Nitric Oxide Synthase Type III
Ligusticum
Herbal Medicine
Cyclic GMP
Nitrates
Nitric Oxide
Proteins
Collagen
tetramethylpyrazine

ASJC Scopus subject areas

  • Pharmacology

引用此文

The antiplatelet activity of tetramethylpyrazine is mediated through activation of NO synthase. / Sheu, Joen Rong; Kan, Ya Chen; Hung, Wei Chun; Lin, Chien-Huang; Yen, Mao Hsiung.

於: Life Sciences, 卷 67, 編號 8, 14.07.2000, p. 937-947.

研究成果: 雜誌貢獻文章

Sheu, Joen Rong ; Kan, Ya Chen ; Hung, Wei Chun ; Lin, Chien-Huang ; Yen, Mao Hsiung. / The antiplatelet activity of tetramethylpyrazine is mediated through activation of NO synthase. 於: Life Sciences. 2000 ; 卷 67, 編號 8. 頁 937-947.
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abstract = "Tetramethylpyrazine (TMPZ) is an active ingredient of a Chinese herbal medicine (Ligusticum wallichii Franchat). In this study, TMPZ (50-200 μM) significantly increased production of nitrate and cyclic GMP in human platelets within a 15-min incubation period. TMPZ concentration-dependently inhibited intracellular Ca2+ mobilization in human platelets stimulated by collagen (5 μg/ml). Furthermore, TMPZ concentration (50 and 200 μM)- and time (15 and 30 min)-dependently triggered endothelial-type constitutive nitric oxide synthase (ecNOS) protein expression in human platelets. These results indicated that TMPZ at micromolar concentrations stimulated nitric oxide production in human platelets via a novel mechanism that activated ecNOS protein expression. (C) 2000 Elsevier Science Inc.",
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AU - Kan, Ya Chen

AU - Hung, Wei Chun

AU - Lin, Chien-Huang

AU - Yen, Mao Hsiung

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AB - Tetramethylpyrazine (TMPZ) is an active ingredient of a Chinese herbal medicine (Ligusticum wallichii Franchat). In this study, TMPZ (50-200 μM) significantly increased production of nitrate and cyclic GMP in human platelets within a 15-min incubation period. TMPZ concentration-dependently inhibited intracellular Ca2+ mobilization in human platelets stimulated by collagen (5 μg/ml). Furthermore, TMPZ concentration (50 and 200 μM)- and time (15 and 30 min)-dependently triggered endothelial-type constitutive nitric oxide synthase (ecNOS) protein expression in human platelets. These results indicated that TMPZ at micromolar concentrations stimulated nitric oxide production in human platelets via a novel mechanism that activated ecNOS protein expression. (C) 2000 Elsevier Science Inc.

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