摘要
Berberine is a natural isoquinoline alkaloid found in plants of the Ranunculaceae and Berberidaceae families. Extracts from berberine-containing plants have been used as traditional Chinese folk remedies for centuries. The antihypertensive effects of the herberine derivative 6-protoberberine (PTB-6) were studied in spontaneously hypertensive rats (SHRs). In conscious SHRs, PTB-6 lowered the systolic blood pressure in a dose-dependent manner (6-PTB: 5 mg/kg, -31.1 ± 1.6 mmHg; 10 mg/kg, -42.4 ± 3.1 mmHg). Cardiac output using the thermodilution method was reduced in PTB-6-treated anesthetized SHRs with a tendency to decrease in heart rate. Injection of PTB-6 into the intraceral ventricles of SHRs lowered the systolic arterial blood pressure and heart rate. The berberine derivative PTB-6 is an effective antihypertensive agent. The mechanism of the antihypertensive effect of PTB-6 is probably through a central sympatholytic effect.
原文 | 英語 |
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頁(從 - 到) | 283-289 |
頁數 | 7 |
期刊 | Pharmacology |
卷 | 59 |
發行號 | 6 |
DOIs | |
出版狀態 | 已發佈 - 12月 1999 |
ASJC Scopus subject areas
- 藥理