The antihypertensive effect of the berberine derivative 6-protoberberine in spontaneously hypertensive rats

Ju Chi Liu, Paul Chan, Yi Jen Chen, Brian Tomlinson, Sheu Fang Hong, Juei Tang Cheng

研究成果: 雜誌貢獻文章同行評審

36 引文 斯高帕斯(Scopus)

摘要

Berberine is a natural isoquinoline alkaloid found in plants of the Ranunculaceae and Berberidaceae families. Extracts from berberine-containing plants have been used as traditional Chinese folk remedies for centuries. The antihypertensive effects of the herberine derivative 6-protoberberine (PTB-6) were studied in spontaneously hypertensive rats (SHRs). In conscious SHRs, PTB-6 lowered the systolic blood pressure in a dose-dependent manner (6-PTB: 5 mg/kg, -31.1 ± 1.6 mmHg; 10 mg/kg, -42.4 ± 3.1 mmHg). Cardiac output using the thermodilution method was reduced in PTB-6-treated anesthetized SHRs with a tendency to decrease in heart rate. Injection of PTB-6 into the intraceral ventricles of SHRs lowered the systolic arterial blood pressure and heart rate. The berberine derivative PTB-6 is an effective antihypertensive agent. The mechanism of the antihypertensive effect of PTB-6 is probably through a central sympatholytic effect.

原文英語
頁(從 - 到)283-289
頁數7
期刊Pharmacology
59
發行號6
出版狀態已發佈 - 十二月 1999

ASJC Scopus subject areas

  • Pharmacology

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