The anti-apoptotic protein survivin is overexpressed in patients with primary brain lymphoma

Junn Liang Chang, Dai W. Liu, Lai F. Sheu, Wei H. Lee

研究成果: 雜誌貢獻文章

摘要

Background: Survivin is a novel secreted inhibitor of apoptosis protein. It is overexpressed in various human cancers, but is undetectable in healthy differentiated tissues. To investigate the role of anti-apoptosis-related gene expression, the survivin protein was studied in subjects with primary brain lymphoma. Methods: The medical records of 18 patients with primary brain lymphoma (PBL) were analyzed. Survivin expression in tumor cells was determined using an immunohistochemical assay using mouse monoclonal antibodies to survivin. Cell phenotype classifications were evaluated using CD79a, CD20, CD3, and CD45RO biomarkers in paraffin-embedded specimens. Results: The results of the immunohistochemical assay showed that 14 of the 18 (78%) individuals with PBL had overexpression of survivin in virtually all tumor cells. These 18 immunocompetent individuals had positive immunoreactivity for CD79a, CD20, which revealed the characteristics of diffuse large B-cell lymphoma of the brain. Conclusions: Our preliminary findings suggest that the apoptotic inhibitor, survivin, may be an important biomarker in the development, pathogenesis and tumorigenesis of primary brain lymphoma, and may also be a candidate target molecule for therapeutic intervention. Further investigations with a larger sample size are recommended.

原文英語
頁(從 - 到)13-19
頁數7
期刊Journal of Medical Sciences (Taiwan)
25
發行號1
出版狀態已發佈 - 二月 2005
對外發佈Yes

指紋

Apoptosis Regulatory Proteins
Lymphoma
Brain
Biomarkers
Inhibitor of Apoptosis Proteins
Neoplasms
Lymphoma, Large B-Cell, Diffuse
Paraffin
Sample Size
Medical Records
Carcinogenesis
Monoclonal Antibodies
Apoptosis
Phenotype
Gene Expression
Proteins

ASJC Scopus subject areas

  • Medicine(all)

引用此文

The anti-apoptotic protein survivin is overexpressed in patients with primary brain lymphoma. / Chang, Junn Liang; Liu, Dai W.; Sheu, Lai F.; Lee, Wei H.

於: Journal of Medical Sciences (Taiwan), 卷 25, 編號 1, 02.2005, p. 13-19.

研究成果: 雜誌貢獻文章

@article{f41f5cc4d74d4094ac475f68910451f1,
title = "The anti-apoptotic protein survivin is overexpressed in patients with primary brain lymphoma",
abstract = "Background: Survivin is a novel secreted inhibitor of apoptosis protein. It is overexpressed in various human cancers, but is undetectable in healthy differentiated tissues. To investigate the role of anti-apoptosis-related gene expression, the survivin protein was studied in subjects with primary brain lymphoma. Methods: The medical records of 18 patients with primary brain lymphoma (PBL) were analyzed. Survivin expression in tumor cells was determined using an immunohistochemical assay using mouse monoclonal antibodies to survivin. Cell phenotype classifications were evaluated using CD79a, CD20, CD3, and CD45RO biomarkers in paraffin-embedded specimens. Results: The results of the immunohistochemical assay showed that 14 of the 18 (78{\%}) individuals with PBL had overexpression of survivin in virtually all tumor cells. These 18 immunocompetent individuals had positive immunoreactivity for CD79a, CD20, which revealed the characteristics of diffuse large B-cell lymphoma of the brain. Conclusions: Our preliminary findings suggest that the apoptotic inhibitor, survivin, may be an important biomarker in the development, pathogenesis and tumorigenesis of primary brain lymphoma, and may also be a candidate target molecule for therapeutic intervention. Further investigations with a larger sample size are recommended.",
keywords = "Apoptosis, Brain lymphoma, Survivin",
author = "Chang, {Junn Liang} and Liu, {Dai W.} and Sheu, {Lai F.} and Lee, {Wei H.}",
year = "2005",
month = "2",
language = "English",
volume = "25",
pages = "13--19",
journal = "Journal of Medical Sciences",
issn = "1011-4564",
publisher = "國防醫學院",
number = "1",

}

TY - JOUR

T1 - The anti-apoptotic protein survivin is overexpressed in patients with primary brain lymphoma

AU - Chang, Junn Liang

AU - Liu, Dai W.

AU - Sheu, Lai F.

AU - Lee, Wei H.

PY - 2005/2

Y1 - 2005/2

N2 - Background: Survivin is a novel secreted inhibitor of apoptosis protein. It is overexpressed in various human cancers, but is undetectable in healthy differentiated tissues. To investigate the role of anti-apoptosis-related gene expression, the survivin protein was studied in subjects with primary brain lymphoma. Methods: The medical records of 18 patients with primary brain lymphoma (PBL) were analyzed. Survivin expression in tumor cells was determined using an immunohistochemical assay using mouse monoclonal antibodies to survivin. Cell phenotype classifications were evaluated using CD79a, CD20, CD3, and CD45RO biomarkers in paraffin-embedded specimens. Results: The results of the immunohistochemical assay showed that 14 of the 18 (78%) individuals with PBL had overexpression of survivin in virtually all tumor cells. These 18 immunocompetent individuals had positive immunoreactivity for CD79a, CD20, which revealed the characteristics of diffuse large B-cell lymphoma of the brain. Conclusions: Our preliminary findings suggest that the apoptotic inhibitor, survivin, may be an important biomarker in the development, pathogenesis and tumorigenesis of primary brain lymphoma, and may also be a candidate target molecule for therapeutic intervention. Further investigations with a larger sample size are recommended.

AB - Background: Survivin is a novel secreted inhibitor of apoptosis protein. It is overexpressed in various human cancers, but is undetectable in healthy differentiated tissues. To investigate the role of anti-apoptosis-related gene expression, the survivin protein was studied in subjects with primary brain lymphoma. Methods: The medical records of 18 patients with primary brain lymphoma (PBL) were analyzed. Survivin expression in tumor cells was determined using an immunohistochemical assay using mouse monoclonal antibodies to survivin. Cell phenotype classifications were evaluated using CD79a, CD20, CD3, and CD45RO biomarkers in paraffin-embedded specimens. Results: The results of the immunohistochemical assay showed that 14 of the 18 (78%) individuals with PBL had overexpression of survivin in virtually all tumor cells. These 18 immunocompetent individuals had positive immunoreactivity for CD79a, CD20, which revealed the characteristics of diffuse large B-cell lymphoma of the brain. Conclusions: Our preliminary findings suggest that the apoptotic inhibitor, survivin, may be an important biomarker in the development, pathogenesis and tumorigenesis of primary brain lymphoma, and may also be a candidate target molecule for therapeutic intervention. Further investigations with a larger sample size are recommended.

KW - Apoptosis

KW - Brain lymphoma

KW - Survivin

UR - http://www.scopus.com/inward/record.url?scp=14644410386&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=14644410386&partnerID=8YFLogxK

M3 - Article

AN - SCOPUS:14644410386

VL - 25

SP - 13

EP - 19

JO - Journal of Medical Sciences

JF - Journal of Medical Sciences

SN - 1011-4564

IS - 1

ER -