The analgesic effect of nalbuphine and its long-acting prodrug, nalbuphine arachidicate, in rats

Kuo Feng Huang, Yoa Pu Hu, Shung Tai Ho, Yi Ling Chen, Jhi Joung Wang

研究成果: 雜誌貢獻文章

摘要

Nalbuphine is an opioid-analgesic with agonist-antagonist properties. Recently, we synthesized a nalbuphine prodrug, nalbuphine arachidicate. The aim of the present study was to evaluate the analgesic effect and the analgesic duration of this prodrug. Male Sprague-Dawley rats (n=10 in each group) were used. Nalbuphine arachidicate was prepared in an oily solution dosage form and injected intramuscularly at a dosage of 25 μmol/kg. A nalbuphine HCl solution was injected intramuscularly at a dosage of 25 μmol/kg in the control group. The analgesic effect of nalbuphine arachidicate was assessed using the cold-ethanol tail-flick test (-20°C) and compared with that of nalbuphine HCl. The results show that both nalbuphine arachidicate and nalbuphine HCl demonstrate significant analgesic effects. The analgesic duration of nalbuphine arachidicate (78 h) was much longer than that of nalbuphine HCl (2 h). This fascinating finding is worthy of further evaluation.
原文英語
頁(從 - 到)283-289
頁數7
期刊Formosan Journal of Surgery
35
發行號6
出版狀態已發佈 - 一月 1 2002
對外發佈Yes

    指紋

ASJC Scopus subject areas

  • Surgery

引用此

Huang, K. F., Hu, Y. P., Ho, S. T., Chen, Y. L., & Wang, J. J. (2002). The analgesic effect of nalbuphine and its long-acting prodrug, nalbuphine arachidicate, in rats. Formosan Journal of Surgery, 35(6), 283-289.