The Ambivalent Role of lncRNA Xist in Carcinogenesis

Yung Kang Chen, Yun Yen

研究成果: 雜誌貢獻文章同行評審

9 引文 斯高帕斯(Scopus)

摘要

Long non-coding RNA (lncRNA) Xist has emerged as a key modulator in dosage compensation by randomly inactivating one of the X chromosomes in mammals during embryonic development. Dysregulation of X chromosome inactivation (XCI) due to deletion of Xist has been proven to induce hematologic cancer in mice. However, this phenomenon is not consistent in humans as growing evidence suggests Xist can suppress or promote cancer growth in different organs of the human body. In this review, we discuss recent advances of XCI in human embryonic stem cells and provide an explanation for the seemingly contradictory roles of Xist in development of human cancer.

原文英語
頁(從 - 到)314-323
頁數10
期刊Stem Cell Reviews and Reports
15
發行號2
DOIs
出版狀態已發佈 - 四月 15 2019

ASJC Scopus subject areas

  • 細胞生物學
  • 癌症研究

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