Tetramethylpyrazine as potassium channel opener to lower calcium influx into cultured aortic smooth muscle cells

Chin Chuan Tsai, Tung-Iuan Lai, Wei Chan Huang, Tzyylin Yang, I. Min Liu, Kar Lok Wong, Paul Chan, Juei Tang Cheng

研究成果: 雜誌貢獻文章同行評審

13 引文 斯高帕斯(Scopus)

摘要

In the present study, the effect of tetramethylpyrazine (TMP) on calcium (Ca2+) influx was investigated in cultured vascular smooth muscle (A7r5) cells using Fura-2 as an indicator. The increase of Ca2+ concentration in A7r5 cells produced by vasopressin or phenylephrine was attenuated by TMP from 0.01 μmol/L to 1 mmol/L. The decrease in the intracellular potassium concentration in A7r5 cells by TMP from 0.01 μmol/L to 10 μmol/L was characterized using PBFI/AM. Inhibitors specific to the small conductance calcium-activated potassium (SKCa) channel or the ATP-sensitive potassium (KATP) channel abolished the actions of TMP. The obtained results indicate that the decrease of Ca2+ influx into A7r5 cells by TMP is mainly mediated by the opening of potassium channels.

原文英語
頁(從 - 到)557-558
頁數2
期刊Planta Medica
69
發行號6
DOIs
出版狀態已發佈 - 6月 1 2003

ASJC Scopus subject areas

  • 分析化學
  • 分子醫學
  • 藥理
  • 藥學科學
  • 藥物發現
  • 補充和替代醫學
  • 有機化學

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