摘要
| 原文 | 英語 |
|---|---|
| 頁（從 - 到） | 279-293 |
| 頁數 | 15 |
| 期刊 | Endocrine-Related Cancer |
| 卷 | 25 |
| 發行號 | 3 |
| DOIs | |
| 出版狀態 | 已發佈 - 三月 1 2018 |
指紋
ASJC Scopus subject areas
- Endocrinology, Diabetes and Metabolism
- Oncology
- Endocrinology
- Cancer Research
引用此文
Tetrac downregulates β-catenin and HMGA2 to promote the effect of resveratrol in colon cancer. / Nana, André Wendindondé; Chin, Yu Tang; Lin, Chi Yu; Ho, Yih; Bennett, James A.; Shih, Ya Jung; Chen, Yi Ru; Changou, Chun A.; Pedersen, Jens Z.; Incerpi, Sandra; Liu, Leroy F.; Whang-Peng, Jacqueline; Fu, Earl; Li, Wen Shan; Mousa, Shaker A.; Lin, Hung Yun; Davis, Paul J.
於: Endocrine-Related Cancer, 卷 25, 編號 3, 01.03.2018, p. 279-293.研究成果: 雜誌貢獻 › 文章
}
TY - JOUR
T1 - Tetrac downregulates β-catenin and HMGA2 to promote the effect of resveratrol in colon cancer
AU - Nana, André Wendindondé
AU - Chin, Yu Tang
AU - Lin, Chi Yu
AU - Ho, Yih
AU - Bennett, James A.
AU - Shih, Ya Jung
AU - Chen, Yi Ru
AU - Changou, Chun A.
AU - Pedersen, Jens Z.
AU - Incerpi, Sandra
AU - Liu, Leroy F.
AU - Whang-Peng, Jacqueline
AU - Fu, Earl
AU - Li, Wen Shan
AU - Mousa, Shaker A.
AU - Lin, Hung Yun
AU - Davis, Paul J.
PY - 2018/3/1
Y1 - 2018/3/1
N2 - The molecular pathogenesis of colorectal cancer encompasses the activation of several oncogenic signaling pathways that include the Wnt/β-catenin pathway and the overexpression of high mobility group protein A2 (HMGA2). Resveratrol - the polyphenolic phytoalexin - binds to integrin αvβ3 to induce apoptosis in cancer cells via cyclooxygenase 2 (COX-2) nuclear accumulation and p53-dependent apoptosis. Tetraiodothyroacetic acid (tetrac) is a de-aminated derivative of l-thyroxine (T4), which - in contrast to the parental hormone - impairs cancer cell proliferation. In the current study, we found that tetrac promoted resveratrol-induced anti-proliferation in colon cancer cell lines, in primary cultures of colon cancer cells, and in vivo. The mechanisms implicated in this action involved the downregulation of nuclear β-catenin and HMGA2, which are capable of compromising resveratrol-induced COX-2 nuclear translocation. Silencing of either β-catenin or HMGA2 promoted resveratrol-induced anti-proliferation and COX-2 nuclear accumulation which is essential for integrin αvβ3-mediatedresveratrol- induced apoptosis in cancer cells. Concurrently, tetrac enhanced nuclear abundance of chibby family member 1, the nuclear β-catenin antagonist, which may further compromise the nuclear β-catenin-dependent gene expression and proliferation. Taken together, these results suggest that tetrac targets β-catenin and HMGA2 to promote resveratrol-induced-anti-proliferation in colon cancers, highlighting its potential in anti-cancer combination therapy.
AB - The molecular pathogenesis of colorectal cancer encompasses the activation of several oncogenic signaling pathways that include the Wnt/β-catenin pathway and the overexpression of high mobility group protein A2 (HMGA2). Resveratrol - the polyphenolic phytoalexin - binds to integrin αvβ3 to induce apoptosis in cancer cells via cyclooxygenase 2 (COX-2) nuclear accumulation and p53-dependent apoptosis. Tetraiodothyroacetic acid (tetrac) is a de-aminated derivative of l-thyroxine (T4), which - in contrast to the parental hormone - impairs cancer cell proliferation. In the current study, we found that tetrac promoted resveratrol-induced anti-proliferation in colon cancer cell lines, in primary cultures of colon cancer cells, and in vivo. The mechanisms implicated in this action involved the downregulation of nuclear β-catenin and HMGA2, which are capable of compromising resveratrol-induced COX-2 nuclear translocation. Silencing of either β-catenin or HMGA2 promoted resveratrol-induced anti-proliferation and COX-2 nuclear accumulation which is essential for integrin αvβ3-mediatedresveratrol- induced apoptosis in cancer cells. Concurrently, tetrac enhanced nuclear abundance of chibby family member 1, the nuclear β-catenin antagonist, which may further compromise the nuclear β-catenin-dependent gene expression and proliferation. Taken together, these results suggest that tetrac targets β-catenin and HMGA2 to promote resveratrol-induced-anti-proliferation in colon cancers, highlighting its potential in anti-cancer combination therapy.
KW - Colorectal cancers
KW - HMGA2
KW - Resveratrol
KW - Tetraiodothyroacetic acid
KW - β-catenin
UR - http://www.scopus.com/inward/record.url?scp=85042584220&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85042584220&partnerID=8YFLogxK
U2 - 10.1530/ERC-17-0450
DO - 10.1530/ERC-17-0450
M3 - Article
C2 - 29255096
AN - SCOPUS:85042584220
VL - 25
SP - 279
EP - 293
JO - Endocrine-Related Cancer
JF - Endocrine-Related Cancer
SN - 1351-0088
IS - 3
ER -