TY - JOUR
T1 - Tetanization-induced pelvic-to-pudendal reflex plasticity in anesthetized rats
AU - Lin, Tzer Bin
PY - 2004/8
Y1 - 2004/8
N2 - Reflex plasticity between pelvic afferent and pudendal efferent nerve fibers was examined in anesthetized rats, Brief high-frequency electric stimulation (300 pulses at 100 Hz) of the pelvic nerve afferent fiber produced a long-lasting potentiation of the pelvic-to-pudendal reflex (PPR). This tetanization-induced potentiation was abolished by a selective N-methyl-D-aspartate (NMDA) receptor antagonist and attenuated by a non-NMDA excitatory amino acid receptor antagonist, However, the GABAA- receptor antagonist had no effect on this potentiation. Both intrathecal glutamate (0.1 mM, 2-5 μl it) and NMDA (0.1 mM, 2-5 μl it) induced a potentiation of PPR similar to that of tetanization. Agonist-induced potentiation was shorter than tetanization-induced potentiation. The duration of the contraction wave of intraurethral pressure, elicited by PPR, was elongated by tetanization-induced potentiation, whereas the peak pressure was not affected. All these results demonstrate that brief high-frequency stimulation of the pelvic nerve afferent fiber can induce a distinct and long-lasting modulation in PPR activity and this change may be involved in nociceptive C afferent-induced obstructive urinary dysfunctions.
AB - Reflex plasticity between pelvic afferent and pudendal efferent nerve fibers was examined in anesthetized rats, Brief high-frequency electric stimulation (300 pulses at 100 Hz) of the pelvic nerve afferent fiber produced a long-lasting potentiation of the pelvic-to-pudendal reflex (PPR). This tetanization-induced potentiation was abolished by a selective N-methyl-D-aspartate (NMDA) receptor antagonist and attenuated by a non-NMDA excitatory amino acid receptor antagonist, However, the GABAA- receptor antagonist had no effect on this potentiation. Both intrathecal glutamate (0.1 mM, 2-5 μl it) and NMDA (0.1 mM, 2-5 μl it) induced a potentiation of PPR similar to that of tetanization. Agonist-induced potentiation was shorter than tetanization-induced potentiation. The duration of the contraction wave of intraurethral pressure, elicited by PPR, was elongated by tetanization-induced potentiation, whereas the peak pressure was not affected. All these results demonstrate that brief high-frequency stimulation of the pelvic nerve afferent fiber can induce a distinct and long-lasting modulation in PPR activity and this change may be involved in nociceptive C afferent-induced obstructive urinary dysfunctions.
KW - N-methyl-D-aspartate; DL-α-amino-3- hydroxy-5-methylisoxazole-propionic acid
KW - Pelvic nerve
KW - Pudendal nerve
UR - http://www.scopus.com/inward/record.url?scp=3242704206&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=3242704206&partnerID=8YFLogxK
U2 - 10.1152/ajprenal.00325.2003
DO - 10.1152/ajprenal.00325.2003
M3 - Article
C2 - 15271687
AN - SCOPUS:3242704206
VL - 287
JO - American Journal of Physiology - Renal Physiology
JF - American Journal of Physiology - Renal Physiology
SN - 1931-857X
IS - 2 56-2
ER -