Testosterone inhibits prostacyclin production by rat aortic smooth muscle cells in culture

Junko Nakao, Wen Chang Chang, Sei Itsu Murota, Hajime Orimo

研究成果: 雜誌貢獻文章

78 引文 (Scopus)

摘要

The effects of testosterone on cell proliferation and prostacyclin production were investigated using rat aortic smooth muscle cells in culture. Testosterone at 10-10 - 10-6 M did not have any significant effect on cell proliferation, but it significantly inhibited prostacyclin production by the cells. Maximal inhibition of prostacyclin production (70%) was observed when cells were treated with a physiological concentration of 10-8M testosterone for 5 consecutive days. These results suggest that testosterone may stimulate thrombus formation and accelerate atherosclerosis by suppressing prostacyclin production in arterial smooth muscle cells.

原文英語
頁(從 - 到)203-209
頁數7
期刊Atherosclerosis
39
發行號2
DOIs
出版狀態已發佈 - 1981
對外發佈Yes

指紋

Epoprostenol
Smooth Muscle Myocytes
Testosterone
Cell Culture Techniques
Cell Proliferation
Atherosclerosis
Thrombosis

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

引用此文

Testosterone inhibits prostacyclin production by rat aortic smooth muscle cells in culture. / Nakao, Junko; Chang, Wen Chang; Murota, Sei Itsu; Orimo, Hajime.

於: Atherosclerosis, 卷 39, 編號 2, 1981, p. 203-209.

研究成果: 雜誌貢獻文章

Nakao, Junko ; Chang, Wen Chang ; Murota, Sei Itsu ; Orimo, Hajime. / Testosterone inhibits prostacyclin production by rat aortic smooth muscle cells in culture. 於: Atherosclerosis. 1981 ; 卷 39, 編號 2. 頁 203-209.
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