Testicular sperm is superior to ejaculated sperm for ICSI in cryptozoospermia: An update systematic review and meta-analysis

Yi No Kang, Ya Wen Hsiao, Chien Yu Chen, Chien Chih Wu

研究成果: 雜誌貢獻回顧型文獻

4 引文 (Scopus)

摘要

Intracytoplasmic sperm injection (ICSI) is well established and provides patients with severely impaired sperm quality with an opportunity to father a child. However, previous studies do not clearly indicate whether male with cryptozoospermia should use testicular sperm or ejaculated sperm for ICSI. The newest systematic review of this topic also gave a controversial conclusion that was based on incorrect pooling result. Moreover, two clinical studies published after the systematic review. In the present update systematic review and meta-analysis, a comprehensive citation search for relevant studies was performed using the Cochrane library databases, Embase, Ovid MEDLINE, PubMed, ScienceDirect, Scopus, and Web of Science up to September 2017. The search returned 313 records, in which six studies were included in quantitative synthesis. These studies involved 578 male infertility patients who had undergone 761 ICSI cycles. The risk ratios favour fresh testicular sperm for good quality embryo rate (1.17, 95% CI 1.05-1.30, P = 0.005), implantation rate (95% CI 1.02-2.26, P = 0.04), and pregnancy rate (RR = 1.74, 95% CI 1.20-2.52, P = 0.004). In conclusion, the existing evidence suggests that testicular sperm is better than ejaculated sperm for ICSI in male with cryptozoospermia.
原文英語
文章編號7874
期刊Scientific Reports
8
發行號1
DOIs
出版狀態已發佈 - 十二月 1 2018

指紋

Intracytoplasmic Sperm Injections
Meta-Analysis
Spermatozoa
Male Infertility
Pregnancy Rate
PubMed
MEDLINE
Fathers
Libraries
Embryonic Structures
Odds Ratio
Databases

ASJC Scopus subject areas

  • General

引用此文

Testicular sperm is superior to ejaculated sperm for ICSI in cryptozoospermia : An update systematic review and meta-analysis. / Kang, Yi No; Hsiao, Ya Wen; Chen, Chien Yu; Wu, Chien Chih.

於: Scientific Reports, 卷 8, 編號 1, 7874, 01.12.2018.

研究成果: 雜誌貢獻回顧型文獻

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abstract = "Intracytoplasmic sperm injection (ICSI) is well established and provides patients with severely impaired sperm quality with an opportunity to father a child. However, previous studies do not clearly indicate whether male with cryptozoospermia should use testicular sperm or ejaculated sperm for ICSI. The newest systematic review of this topic also gave a controversial conclusion that was based on incorrect pooling result. Moreover, two clinical studies published after the systematic review. In the present update systematic review and meta-analysis, a comprehensive citation search for relevant studies was performed using the Cochrane library databases, Embase, Ovid MEDLINE, PubMed, ScienceDirect, Scopus, and Web of Science up to September 2017. The search returned 313 records, in which six studies were included in quantitative synthesis. These studies involved 578 male infertility patients who had undergone 761 ICSI cycles. The risk ratios favour fresh testicular sperm for good quality embryo rate (1.17, 95{\%} CI 1.05-1.30, P = 0.005), implantation rate (95{\%} CI 1.02-2.26, P = 0.04), and pregnancy rate (RR = 1.74, 95{\%} CI 1.20-2.52, P = 0.004). In conclusion, the existing evidence suggests that testicular sperm is better than ejaculated sperm for ICSI in male with cryptozoospermia.",
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