Teratogenic and cytogenetic effects of hycanthone in mice and rabbits

S. M. Sieber, J. Whang‐Peng, R. H. Adamson

研究成果: 雜誌貢獻文章同行評審

16 引文 斯高帕斯(Scopus)

摘要

Hycanthone administered daily to pregnant mice at 3 dose levels on days 61–11 of gestation produced embryolethality and a depression of fetal body weights. At 12.5 mg/kg, no teratogenic effects were observed; at 25 mg/kg, fetal malforrnations occurred, and at 50 mg/kg, more than 90% of the conceptuses were killed. When hycanthone was administered to mice as single injections on days 5–9 of gestation embryolethal and teratogenic effects appeared to be limited to days 6 and 7. In rabbits hycanthone treatment on days 7, 8, and 9 of gestation produced embryolethality at a dose of 25 mg/kg and both embryolethality and teratogenicity at 50 mg/kg. Although hycanthone depressed the mitotic Index and induced chromosomal aberrations in microcultures of blood from untreated rabbits no cytogenetic effects of the drug were observed in either adult or fetal mice and rabbits in vivo.
原文英語
頁(從 - 到)227-236
頁數10
期刊Teratology
10
發行號3
DOIs
出版狀態已發佈 - 一月 1 1974
對外發佈

ASJC Scopus subject areas

  • 胚胎學
  • 毒理學
  • 發展生物學
  • 健康、毒理學和誘變

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