Temporal trends and molecular epidemiology of HIV-1 infection in Taiwan from 1988 to 1998

Yi Ming A. Chen, Kui Li Huang, Ian Jen, Shou Chien Chen, Yuan Chin Liu, Yin Chin Chuang, Jen Chien Wong, Jih Jin Tsai, Yu Chin Lan

研究成果: 雜誌貢獻文章

20 引文 (Scopus)

摘要

Eight hundred and seventy-nine HIV-1-infected patients (comprising 46% of reported HIV-1/AIDS cases in Taiwan) were recruited for this study of the molecular epidemiology of HIV-1 in Taiwan from 1988 to 1998. HIV-1 subtypes were determined using a modified peptide-enzyme immunoassay complemented with DNA sequencing and phylogenetic analysis. Of the 807 HIV-1 infected men, 68.2% were infected with HIV-1B, 29.5% with HIV-1 circulating recombinant form (CRF)01_AE and 2.3% with other subtypes. Of the 72 HIV-1-infected women, 72.2% were infected with HIV-1 CRF01_AE, 13.9% with HIV-1B, and 13.9% with other subtypes. All of 8 foreign-born, Southeast Asian women and 6 of 7 (85.7%) Taiwan-native female commercial sex workers were infected with HIV-1 CRF01_AE. Fourteen of the 33 (42.4%) heterosexual married men with CRF01_AE had transmitted HIV-1 to their wives, whereas only 1 of 17 (5.9%) men with HIV-1 B had transmitted HIV-1 to their spouses (p < .01). Of 18 heterosexual male injecting drug users, 1 of 12 (8.5%) with HIV-1B and 5 of 6 (83.3%) with HIV-1 CRF01_AE had had sexual contact with female commercial sex workers (p < .01). Therefore, in this population, CRF01_AE was preferentially associated with heterosexual risk groups, a finding compatible with differences in transmission capability between B and non-B subtypes.
原文英語
頁(從 - 到)274-282
頁數9
期刊Journal of Acquired Immune Deficiency Syndromes
26
發行號3
DOIs
出版狀態已發佈 - 三月 1 2001
對外發佈Yes

指紋

Molecular Epidemiology
Taiwan
HIV Infections
HIV-1
Heterosexuality
Sex Workers
HIV
Spouses
Drug Users
Immunoenzyme Techniques
DNA Sequence Analysis
Acquired Immunodeficiency Syndrome

ASJC Scopus subject areas

  • Medicine(all)

引用此文

Temporal trends and molecular epidemiology of HIV-1 infection in Taiwan from 1988 to 1998. / Chen, Yi Ming A.; Huang, Kui Li; Jen, Ian; Chen, Shou Chien; Liu, Yuan Chin; Chuang, Yin Chin; Wong, Jen Chien; Tsai, Jih Jin; Lan, Yu Chin.

於: Journal of Acquired Immune Deficiency Syndromes, 卷 26, 編號 3, 01.03.2001, p. 274-282.

研究成果: 雜誌貢獻文章

Chen, Yi Ming A. ; Huang, Kui Li ; Jen, Ian ; Chen, Shou Chien ; Liu, Yuan Chin ; Chuang, Yin Chin ; Wong, Jen Chien ; Tsai, Jih Jin ; Lan, Yu Chin. / Temporal trends and molecular epidemiology of HIV-1 infection in Taiwan from 1988 to 1998. 於: Journal of Acquired Immune Deficiency Syndromes. 2001 ; 卷 26, 編號 3. 頁 274-282.
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abstract = "Eight hundred and seventy-nine HIV-1-infected patients (comprising 46{\%} of reported HIV-1/AIDS cases in Taiwan) were recruited for this study of the molecular epidemiology of HIV-1 in Taiwan from 1988 to 1998. HIV-1 subtypes were determined using a modified peptide-enzyme immunoassay complemented with DNA sequencing and phylogenetic analysis. Of the 807 HIV-1 infected men, 68.2{\%} were infected with HIV-1B, 29.5{\%} with HIV-1 circulating recombinant form (CRF)01_AE and 2.3{\%} with other subtypes. Of the 72 HIV-1-infected women, 72.2{\%} were infected with HIV-1 CRF01_AE, 13.9{\%} with HIV-1B, and 13.9{\%} with other subtypes. All of 8 foreign-born, Southeast Asian women and 6 of 7 (85.7{\%}) Taiwan-native female commercial sex workers were infected with HIV-1 CRF01_AE. Fourteen of the 33 (42.4{\%}) heterosexual married men with CRF01_AE had transmitted HIV-1 to their wives, whereas only 1 of 17 (5.9{\%}) men with HIV-1 B had transmitted HIV-1 to their spouses (p < .01). Of 18 heterosexual male injecting drug users, 1 of 12 (8.5{\%}) with HIV-1B and 5 of 6 (83.3{\%}) with HIV-1 CRF01_AE had had sexual contact with female commercial sex workers (p < .01). Therefore, in this population, CRF01_AE was preferentially associated with heterosexual risk groups, a finding compatible with differences in transmission capability between B and non-B subtypes.",
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AU - Chen, Yi Ming A.

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AU - Jen, Ian

AU - Chen, Shou Chien

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AU - Chuang, Yin Chin

AU - Wong, Jen Chien

AU - Tsai, Jih Jin

AU - Lan, Yu Chin

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N2 - Eight hundred and seventy-nine HIV-1-infected patients (comprising 46% of reported HIV-1/AIDS cases in Taiwan) were recruited for this study of the molecular epidemiology of HIV-1 in Taiwan from 1988 to 1998. HIV-1 subtypes were determined using a modified peptide-enzyme immunoassay complemented with DNA sequencing and phylogenetic analysis. Of the 807 HIV-1 infected men, 68.2% were infected with HIV-1B, 29.5% with HIV-1 circulating recombinant form (CRF)01_AE and 2.3% with other subtypes. Of the 72 HIV-1-infected women, 72.2% were infected with HIV-1 CRF01_AE, 13.9% with HIV-1B, and 13.9% with other subtypes. All of 8 foreign-born, Southeast Asian women and 6 of 7 (85.7%) Taiwan-native female commercial sex workers were infected with HIV-1 CRF01_AE. Fourteen of the 33 (42.4%) heterosexual married men with CRF01_AE had transmitted HIV-1 to their wives, whereas only 1 of 17 (5.9%) men with HIV-1 B had transmitted HIV-1 to their spouses (p < .01). Of 18 heterosexual male injecting drug users, 1 of 12 (8.5%) with HIV-1B and 5 of 6 (83.3%) with HIV-1 CRF01_AE had had sexual contact with female commercial sex workers (p < .01). Therefore, in this population, CRF01_AE was preferentially associated with heterosexual risk groups, a finding compatible with differences in transmission capability between B and non-B subtypes.

AB - Eight hundred and seventy-nine HIV-1-infected patients (comprising 46% of reported HIV-1/AIDS cases in Taiwan) were recruited for this study of the molecular epidemiology of HIV-1 in Taiwan from 1988 to 1998. HIV-1 subtypes were determined using a modified peptide-enzyme immunoassay complemented with DNA sequencing and phylogenetic analysis. Of the 807 HIV-1 infected men, 68.2% were infected with HIV-1B, 29.5% with HIV-1 circulating recombinant form (CRF)01_AE and 2.3% with other subtypes. Of the 72 HIV-1-infected women, 72.2% were infected with HIV-1 CRF01_AE, 13.9% with HIV-1B, and 13.9% with other subtypes. All of 8 foreign-born, Southeast Asian women and 6 of 7 (85.7%) Taiwan-native female commercial sex workers were infected with HIV-1 CRF01_AE. Fourteen of the 33 (42.4%) heterosexual married men with CRF01_AE had transmitted HIV-1 to their wives, whereas only 1 of 17 (5.9%) men with HIV-1 B had transmitted HIV-1 to their spouses (p < .01). Of 18 heterosexual male injecting drug users, 1 of 12 (8.5%) with HIV-1B and 5 of 6 (83.3%) with HIV-1 CRF01_AE had had sexual contact with female commercial sex workers (p < .01). Therefore, in this population, CRF01_AE was preferentially associated with heterosexual risk groups, a finding compatible with differences in transmission capability between B and non-B subtypes.

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