TDP-43 Regulates Coupled Dendritic mRNA Transport-Translation Processes in Co-operation with FMRP and Staufen1

Jen Fei Chu, Pritha Majumder, Biswanath Chatterjee, Shih Ling Huang, Che Kun James Shen

研究成果: 雜誌貢獻文章同行評審

12 引文 斯高帕斯(Scopus)

摘要

Chu et al. explore mechanisms of TDP-43-mediated dendritic mRNA transport, combining molecular approaches, real-time imaging, and an RNA biosensor. Analysis of the kinetics and dynamics of coupled transport-translation processes of Rac1 mRNA in neuronal dendrites demonstrates that TDP-43 regulates these processes in cooperation with FMRP and Staufen1 in different subcompartments.

原文英語
頁(從 - 到)3118-3133.e6
期刊Cell Reports
29
發行號10
DOIs
出版狀態已發佈 - 十二月 3 2019
對外發佈Yes

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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