Chu et al. explore mechanisms of TDP-43-mediated dendritic mRNA transport, combining molecular approaches, real-time imaging, and an RNA biosensor. Analysis of the kinetics and dynamics of coupled transport-translation processes of Rac1 mRNA in neuronal dendrites demonstrates that TDP-43 regulates these processes in cooperation with FMRP and Staufen1 in different subcompartments.
ASJC Scopus subject areas
- Biochemistry, Genetics and Molecular Biology(all)