Tc17 CD8 T cells: Functional plasticity and subset diversity

Hung Rong Yen, Timothy J. Harris, Satoshi Wada, Joseph F. Grosso, Derese Getnet, Monica V. Goldberg, Kai Li Liang, Tullia C. Bruno, Kristin J. Pyle, Siaw Li Chan, Robert A. Anders, Cornelia L. Trimble, Adam J. Adler, Tzou Yien Lin, Drew M. Pardoll, Ching Tai Huang, Charles G. Drake

研究成果: 雜誌貢獻文章

133 引文 斯高帕斯(Scopus)

摘要

IL-17-secreting CD8 T cells (Tc17) have been described in several settings, but little is known regarding their functional characteristics. While Tc1 cells produced IFN-γ and efficiently killed targets, Tc17 cells lacked lytic function in vitro. Interestingly, the small numbers of IFN-γ-positive or IL-17/IFN-γ-double-positive cells generated under Tc17 conditions also lacked lytic activity and expressed a similar pattern of cell surface proteins to IL-17-producing cells. As is the case for Th17 (CD4) cells, STAT3 is important for Tc17 polarization, both in vitro and in vivo. Adoptive transfer of highly purified, Ag-specific IL-17-secreting Tc17 cells into Ag-bearing hosts resulted in near complete conversion to an IFN-γ-secreting phenotype and substantial pulmonary pathology, demonstrating functional plasticity. Tc17 also accumulated to a greater extent than did Tc1 cells, suggesting that adoptive transfer of CD8 T cells cultured in Tc17 conditions may have therapeutic potential for diseases in which IFN-γ-producing cells are desired.
原文英語
頁(從 - 到)7161-7168
頁數8
期刊Journal of Immunology
183
發行號11
DOIs
出版狀態已發佈 - 十二月 1 2009
對外發佈Yes

ASJC Scopus subject areas

  • Immunology
  • Medicine(all)

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    Yen, H. R., Harris, T. J., Wada, S., Grosso, J. F., Getnet, D., Goldberg, M. V., Liang, K. L., Bruno, T. C., Pyle, K. J., Chan, S. L., Anders, R. A., Trimble, C. L., Adler, A. J., Lin, T. Y., Pardoll, D. M., Huang, C. T., & Drake, C. G. (2009). Tc17 CD8 T cells: Functional plasticity and subset diversity. Journal of Immunology, 183(11), 7161-7168. https://doi.org/10.4049/jimmunol.0900368