Taurine exerts robust protection against hypoxia and oxygen/glucose deprivation in human neuroblastoma cell culture

Po Chih Chen, Chunliu Pan, Payam M. Gharibani, Howard Prentice, Jang Yen Wu

研究成果: 書貢獻/報告類型章節

6 引文 斯高帕斯(Scopus)

摘要

Stroke is one of the leading causes of mortality and disability worldwide. There is no effective treatment for stroke despite extensive research. Taurine is a free amino acid which is present at high concentrations in a range of organs including the brain, heart, and retina in mammalian systems. It had been shown that taurine can significantly increase cell survival under stroke conditions using both in vivo and in vitro models. Recently, we have found that several agents including granulocyte colony-stimulating factor (G-CSF), a stem cell enhancer and facilitator; S -methyl- N -diethylthiolcarbamate sulfoxide (DETC-MeSO), an NMDA receptor partial antagonist; sulindac, a potent antioxidant; and taurine, a neuroprotectant and calcium regulator, are effective in protecting against stroke-induced neuronal injury when used alone or in combination in both animal and tissue/cell culture models. In this chapter, we demonstrate that taurine can protect human neuroblastoma cells measured by ATP assay under conditions of hypoxia or oxygen/glucose deprivation (OGD). In addition, we found that taurine exerts its protective function by suppressing the OGD-induced upregulation of endoplasmic reticulum (ER) stress markers and proapoptotic proteins. A model depicting the mode of action of taurine in protecting neuroblastoma cells under OGD conditions is presented.

原文英語
主出版物標題Taurine 8
主出版物子標題Volume 1: The Nervous System, Immune System, Diabetes and the Cardiovascular System
發行者Springer New York LLC
頁面167-175
頁數9
ISBN(列印)9781461461296
DOIs
出版狀態已發佈 - 2013

出版系列

名字Advances in Experimental Medicine and Biology
775
ISSN(列印)0065-2598

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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    Chen, P. C., Pan, C., Gharibani, P. M., Prentice, H., & Wu, J. Y. (2013). Taurine exerts robust protection against hypoxia and oxygen/glucose deprivation in human neuroblastoma cell culture. 於 Taurine 8: Volume 1: The Nervous System, Immune System, Diabetes and the Cardiovascular System (頁 167-175). (Advances in Experimental Medicine and Biology; 卷 775). Springer New York LLC. https://doi.org/10.1007/978-1-4614-6130-2_14