Targeting the delivery of glycan-based paclitaxel prodrugs to cancer cells via glucose transporters

Yih Shyan Lin, Rudeewan Tungpradit, Supachok Sinchaikul, Feng Ming An, Der Zen Liu, Suree Phutrakul, Shui Tein Chen

研究成果: 雜誌貢獻文章同行評審

81 引文 斯高帕斯(Scopus)

摘要

This report describes the synthesis of four novel paclitaxel based prodrugs with glycan conjugation (1-4). Glycans were conjugated using an ester or ether bond as the linker between 2′-paclitaxel and the 2′-glucose or glucuronic acid moiety. These prodrugs showed good water solubility and selective cytotoxicity against cancer cell lines, but showed reduced toxicity toward normal cell lines and cancer cell lines with low expression levels of GLUTs. The ester conjugated prodrug 1 showed the most cytotoxicity among the prodrugs examined and could be transported into cells via GLUTs. Fluorescent and confocal microscopy demonstrated that targeted cells exhibited morphological changes in tubulin and chromosomal alterations that were similar to those observed with paclitaxel treatment. Therefore, these glycan-based prodrugs may be good drug candidates for cancer therapy, and the glycan conjugation approach is an alternative method to enhance the targeted delivery of other drugs to cancer cells that overexpress GLUTs.

原文英語
頁(從 - 到)7428-7441
頁數14
期刊Journal of Medicinal Chemistry
51
發行號23
DOIs
出版狀態已發佈 - 12月 11 2008

ASJC Scopus subject areas

  • 分子醫學
  • 藥物發現

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