Targeting integrins in cancer nanomedicine: Applications in cancer diagnosis and therapy

Ping Hsiu Wu, Abayomi Emmanuel Opadele, Yasuhito Onodera, Jin Min Nam

研究成果: 雜誌貢獻回顧型文獻同行評審

42 引文 斯高帕斯(Scopus)

摘要

Due to advancements in nanotechnology, the application of nanosized materials (nanomaterials) in cancer diagnostics and therapeutics has become a leading area in cancer research. The decoration of nanomaterial surfaces with biological ligands is a major strategy for directing the actions of nanomaterials specifically to cancer cells. These ligands can bind to specific receptors on the cell surface and enable nanomaterials to actively target cancer cells. Integrins are one of the cell surface receptors that regulate the communication between cells and their microenvironment. Several integrins are overexpressed in many types of cancer cells and the tumor microvasculature and function in the mediation of various cellular events. Therefore, the surface modification of nanomaterials with integrin-specific ligands not only increases their binding affinity to cancer cells but also enhances the cellular uptake of nanomaterials through the intracellular trafficking of integrins. Moreover, the integrin-specific ligands themselves interfere with cancer migration and invasion by interacting with integrins, and this finding provides a novel direction for new treatment approaches in cancer nanomedicine. This article reviews the integrin-specific ligands that have been used in cancer nanomedicine and provides an overview of the recent progress in cancer diagnostics and therapeutic strategies involving the use of integrin-targeted nanomaterials.
原文英語
文章編號1783
期刊Cancers
11
發行號11
DOIs
出版狀態已發佈 - 11月 2019

ASJC Scopus subject areas

  • 腫瘤科
  • 癌症研究

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