Targeting c-Myc as a novel approach for hepatocellular carcinoma

Che Pin Lin, Chien Ru Liu, Chun Nin Lee, Tze Sian Chan, H. Eugene Liu

研究成果: 雜誌貢獻文章同行評審

85 引文 斯高帕斯(Scopus)

摘要

Hepatocelluar carcinoma (HCC) is the most lethal cancer in the world. Most HCC over-express c-Myc, which plays a critical role in regulating cellular growth, differentiation and apoptosis in both normal and neoplastic cells. c-Myc is among the most frequently overexpressed genes in human cancers. Overexpression of c-Myc in hepatic cells leads to development of hepatocellular carcinoma. Here, we review the current progress in understanding physiologic function and regulation of c-Myc as well as its role in hepatic carcinogenesis and discuss the association of c-Myc activation in chronic hepatitis B infection and the upregulation of HIF-1/ VEGF. We also explore the possibility of treating HCC by inhibiting c-Myc and examine the pros and cons of such an approach. Although this strategy is currently not available in clinics, with recent advances in better drug design, pharmacokinetics and pharmacogenetics,inhibition of c-Myc might become a novel therapy for HCC in the future.
原文英語
頁(從 - 到)16-20
頁數5
期刊World Journal of Hepatology
2
發行號1
DOIs
出版狀態已發佈 - 2010

ASJC Scopus subject areas

  • Hepatology

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