Tanshinone IIA from Salvia miltiorrhiza induces heme oxygenase-1 expression and inhibits lipopolysaccharide-induced nitric oxide expression in RAW 264.7 cells

研究成果: 雜誌貢獻文章

54 引文 (Scopus)

摘要

Tanshinone IIA exerts anti-inflammatory effects and influences electron transfer reaction in mitochondria. In the present study, we demonstrated that tanshinone IIA increased intracellular production of reactive oxygen species (ROS), which in turn induces heme oxygenase-1 (HO-1) expression in RAW 264.7 macrophages. Tanshinone IIA inhibited COX-2 and iNOS expression in lipopolysaccharide-activated RAW 264.7 macrophages. Inhibition of HO-1 or scavenging of CO significantly reversed the inhibition of LPS-stimulated nitrite accumulation by tanshinone IIA, suggesting a novel role of HO-1 in the anti-inflammatory effect of tanshinone IIA.
原文英語
頁(從 - 到)101-105
頁數5
期刊Mitochondrion
7
發行號1-2
DOIs
出版狀態已發佈 - 二月 2007

指紋

Salvia miltiorrhiza
Heme Oxygenase-1
Lipopolysaccharides
Nitric Oxide
Anti-Inflammatory Agents
Macrophages
Carbon Monoxide
Nitrites
Reactive Oxygen Species
Mitochondria
RAW 264.7 Cells
tanshinone
Electrons

ASJC Scopus subject areas

  • Biophysics

引用此文

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title = "Tanshinone IIA from Salvia miltiorrhiza induces heme oxygenase-1 expression and inhibits lipopolysaccharide-induced nitric oxide expression in RAW 264.7 cells",
abstract = "Tanshinone IIA exerts anti-inflammatory effects and influences electron transfer reaction in mitochondria. In the present study, we demonstrated that tanshinone IIA increased intracellular production of reactive oxygen species (ROS), which in turn induces heme oxygenase-1 (HO-1) expression in RAW 264.7 macrophages. Tanshinone IIA inhibited COX-2 and iNOS expression in lipopolysaccharide-activated RAW 264.7 macrophages. Inhibition of HO-1 or scavenging of CO significantly reversed the inhibition of LPS-stimulated nitrite accumulation by tanshinone IIA, suggesting a novel role of HO-1 in the anti-inflammatory effect of tanshinone IIA.",
keywords = "Cyclooxygenase-2, Heme oxygenase-1, RAW 264.7 macrophages, Tanshinone IIA",
author = "Chen, {Tso Hsiao} and Hsu, {Yu Tern} and Chen, {Cheng Hsien} and Kao, {Shu Hwei} and Lee, {Horng M.}",
year = "2007",
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AU - Chen, Tso Hsiao

AU - Hsu, Yu Tern

AU - Chen, Cheng Hsien

AU - Kao, Shu Hwei

AU - Lee, Horng M.

PY - 2007/2

Y1 - 2007/2

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AB - Tanshinone IIA exerts anti-inflammatory effects and influences electron transfer reaction in mitochondria. In the present study, we demonstrated that tanshinone IIA increased intracellular production of reactive oxygen species (ROS), which in turn induces heme oxygenase-1 (HO-1) expression in RAW 264.7 macrophages. Tanshinone IIA inhibited COX-2 and iNOS expression in lipopolysaccharide-activated RAW 264.7 macrophages. Inhibition of HO-1 or scavenging of CO significantly reversed the inhibition of LPS-stimulated nitrite accumulation by tanshinone IIA, suggesting a novel role of HO-1 in the anti-inflammatory effect of tanshinone IIA.

KW - Cyclooxygenase-2

KW - Heme oxygenase-1

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KW - Tanshinone IIA

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