Synthetic approaches to 2‐substituted 1‐oxo‐ and 3‐oxotetrahydroisoquinolines

Chen‐Yu ‐Y Cheng, Hui‐Bing ‐B Tsai, Mei‐Shan ‐S Lin

研究成果: 雜誌貢獻文章同行評審

26 引文 斯高帕斯(Scopus)

摘要

2‐Substituted homophthalimides 2a‐c were reduced regioselectively with sodium borobydride to carbinol‐lactam intermediates 3a‐c, which were dehydrated, followed by hydrogenation, to give 1‐oxo‐tetrabydroisoquinolines or 3,4‐dihydroisoquinolin‐1(2H)ones 5a‐c. The isomeric 3‐oxo‐tetrahydro‐isoquinolines or 1,4‐dihydroisoquinolin‐3(2H)‐ones 8a‐i were obtained in satisfactory yields via heating 3‐isochromanone (6) with the corresponding amines 7a‐i in the presence of aluminum chloride.
原文英語
頁(從 - 到)73-77
頁數5
期刊Journal of Heterocyclic Chemistry
32
發行號1
DOIs
出版狀態已發佈 - 一月 1 1995
對外發佈

ASJC Scopus subject areas

  • 有機化學

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