@article{a41f605e787b426ea2c2207914b144d8,
title = "Synthesis of S-linked NeuAc-α(2-6)-di-LacNAc bearing liposomes for H1N1 influenza virus inhibition assays",
abstract = "S-NeuAc-α(2-6)-di-LacNAc (5) was efficiently synthesized by a [2+2] followed by a [1+4] glycosylation, and later conjugated with 1,2-dilauroyl-sn-glycero-3-phosphoethanolamine (DLPE) to form both single-layer and multi-layer homogeneous liposomes in the presence of dipalmitoyl phosphatidylcholine (DPPC) and cholesterol. These liposomes were found to be weak inhibitors in both the influenza virus entry assay and the hemagglutination inhibition assay. The single layer liposome was found to more efficiently interfere with the entry of the H1N1 influenza virus into MDCK cells than the multilayer liposome containing 5.",
keywords = "Hemagglutinin, Influenza, Liposome, Sialic acid",
author = "Cheng, {Hou Wen} and Wang, {Hsiao Wen} and Wong, {Tsung Yun} and Yeh, {Hsien Wei} and Chen, {Yi Chun} and Liu, {Der Zen} and Liang, {Pi Hui}",
note = "Funding Information: We acknowledge the Ministry of Science and Technology (MOST 104-2320-B-002-008-MY3 ; 104-2627-M-002-011 ; 105-2627-M-002-009 ; 106-2627-M-002-001 ) and Academia Sinica in Taiwan for financial support. We gratefully thank Professor Y. S. Edmond Cheng at the Genomics Research Center of Academia Sinica for the influenza virus assay and valuable discussion. A Publisher Copyright: {\textcopyright} 2018 Elsevier Ltd",
year = "2018",
month = may,
day = "15",
doi = "10.1016/j.bmc.2018.02.012",
language = "English",
volume = "26",
pages = "2262--2270",
journal = "Bioorganic and Medicinal Chemistry",
issn = "0968-0896",
publisher = "Elsevier Limited",
number = "9",
}