Synthesis of kappa light chains by cell lines containing an 8;22 chromosomal translocation derived from a male homosexual with Burkitt's lymphoma

Ian Magrath, Jan Erikson, Jacqueline Whang-Peng, Hauke Sieverts, Gary Armstrong, David Benjamin, Timothy Triche, Oliver Alabaster, Carlo M. Croce

研究成果: 雜誌貢獻文章同行評審

54 引文 斯高帕斯(Scopus)

摘要

Three cell lines were derived from a homosexual patient with probable acquired immunodeficiency syndrome and Burkitt's lymphoma. The cell lines produce an unusual strain of Epstein-Barr virus which will both transform cord blood lymphocytes and induce early antigens in Raji cells. Translocations between chromosomes 8 and 22 have occurred in all three lines, but the cells synthesize immunoglobulin M with light chains of the κ type, in contrast to the usual concordance between a translocation involving chromosome 22 and λ chain synthesis. Both κ genes and one λ gene are rearranged. These findings indicate either that translocation may occur as a separate event from immunoglobulin gene rearrangement or that the proposed hierarchical sequence of immunoglobulin gene rearrangements is not always adhered to. The data also imply that in cells containing a translocation between the long arm of chromosome 8 and a chromosome bearing an immunoglobulin gene, alteration of cellular myc expression may occur regardless of the immunoglobulin gene that is expressed.
原文英語
頁(從 - 到)1094-1098
頁數5
期刊Science
222
發行號4628
出版狀態已發佈 - 一月 1 1983
對外發佈Yes

ASJC Scopus subject areas

  • General

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