Synthesis of Ethyl 4(1H)‐Oxopyrimido[1,2‐a]perimidine‐3‐carboxylate

Kang‐Chien ‐C Liu, Hsu‐Shan ‐S Huang

研究成果: 雜誌貢獻文章

2 引文 斯高帕斯(Scopus)

摘要

In a recent communication1), we reported the synthesis of some biologically interesting 1‐substituted 3‐(2‐perimidyl)‐ ureas starting from 2‐aminoperimidine (1a). Because of the presence of a 1,3‐dinucleophilic center in this molecule, 1a might undergo cyclocondensation with appropriate dielectrophiles. So this compound might be a useful synthon for the generation of novel fused perimidine derivatives. In an orientation experiment, we found that the reaction of 1a HBr with dimethyl acetylenedicarboxylate in the presence of Et3N proceeded smoothly and afforded methyl 4(1H)‐oxopyrimido[1,2‐a]perimidine‐2‐carboxylate 2a in 52% yield2). The structure ov 2a was assigned on the basis of spectral analysis.
原文英語
頁(從 - 到)303-304
頁數2
期刊Archiv der Pharmazie
322
發行號5
DOIs
出版狀態已發佈 - 1989
對外發佈Yes

ASJC Scopus subject areas

  • Pharmaceutical Science
  • Drug Discovery

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