Synthesis of a chlorogenin glycoside library using an orthogonal protecting group strategy

Ying Hsin Wang, Hsien Wei Yeh, Hsiao Wen Wang, Chia Chun Yu, Jih Hwa Guh, Der Zen Liu, Pi Hui Liang

研究成果: 雜誌貢獻文章同行評審

12 引文 斯高帕斯(Scopus)

摘要

Naturally occurring spirostanol saponins bear a chacotriose, α-l-rhamnopyranosyl-(1→2)-[α-l-rhamnopyranosyl-(1→4)] -β-d-glucopyranose residue as the oligosaccharide moiety which is believed to be important for biological activity. Herein the development of a concise, combinatorial method for the synthesis of two series of glycan variants at the 2′ and/or 4′ positions of chacotriose is described and the structure-activity relationships of the glycone part at 3-OH of chlorogenin investigated. These compounds were found to be weakly-cytotoxic toward leukemia cell lines CCRF and HL-20, indicating that the chacotriose moiety is important for anticancer activity.

原文英語
頁(從 - 到)118-135
頁數18
期刊Carbohydrate Research
375
DOIs
出版狀態已發佈 - 2013

ASJC Scopus subject areas

  • 生物化學
  • 分析化學
  • 有機化學

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