Synthesis of 2′-paclitaxel methyl 2-glucopyranosyl succinate for specific targeted delivery to cancer cells

Der Zen Liu, Supachok Sinchaikul, Peddiahgari Vasu Govardhana Reddy, Meng Yang Chang, Shui Tein Chen

研究成果: 雜誌貢獻文章

26 引文 (Scopus)

摘要

A novel glucose-conjugated paclitaxel 5 was synthesized using succinic acid as linker between 2′-paclitaxel and methyl 2′-glucopyranose. 5 has not only improved the pharmaceutical properties of paclitaxel, such as solubility and stability, but also enhanced the specific target delivery to MCF-7 cells without the cytotoxicity against normal cells. Therefore, the glucose conjugation may be potentially used in the targeted delivery of other drugs into cells via glucose transporters (GLUTs) for cancer therapy.

原文英語
頁(從 - 到)617-620
頁數4
期刊Bioorganic and Medicinal Chemistry Letters
17
發行號3
DOIs
出版狀態已發佈 - 二月 1 2007

指紋

Paclitaxel
Cells
Glucose
Neoplasms
Facilitative Glucose Transport Proteins
MCF-7 Cells
Succinic Acid
Cytotoxicity
Pharmaceutical Preparations
Solubility
2'-paclitaxel methyl 2-glucopyranosyl succinate
Therapeutics

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Organic Chemistry
  • Drug Discovery
  • Pharmaceutical Science

引用此文

Synthesis of 2′-paclitaxel methyl 2-glucopyranosyl succinate for specific targeted delivery to cancer cells. / Liu, Der Zen; Sinchaikul, Supachok; Reddy, Peddiahgari Vasu Govardhana; Chang, Meng Yang; Chen, Shui Tein.

於: Bioorganic and Medicinal Chemistry Letters, 卷 17, 編號 3, 01.02.2007, p. 617-620.

研究成果: 雜誌貢獻文章

Liu, Der Zen ; Sinchaikul, Supachok ; Reddy, Peddiahgari Vasu Govardhana ; Chang, Meng Yang ; Chen, Shui Tein. / Synthesis of 2′-paclitaxel methyl 2-glucopyranosyl succinate for specific targeted delivery to cancer cells. 於: Bioorganic and Medicinal Chemistry Letters. 2007 ; 卷 17, 編號 3. 頁 617-620.
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AU - Chang, Meng Yang

AU - Chen, Shui Tein

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